Whole genome sequence analysis of Mycobacterium suricattae

Anzaan Dippenaar; Sven David Charles Parsons; Samantha Leigh Sampson; Ruben Gerhard Van Der Merwe; Julian Ashley Drewe; Abdallah Abdallah; Kabengele Keith Siame; Nicolaas Claudius Gey Van Pittius; Paul David Van Helden; Arnab Pain; Robin Mark Warren

doi:10.1016/j.tube.2015.10.001

Whole genome sequence analysis of Mycobacterium suricattae

Anzaan Dippenaar, Sven David Charles Parsons, Samantha Leigh Sampson, Ruben Gerhard Van Der Merwe, Julian Ashley Drewe, Abdallah Abdallah, Kabengele Keith Siame, Nicolaas Claudius Gey Van Pittius, Paul David Van Helden, Arnab Pain, Robin Mark Warren

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Tuberculosis occurs in various mammalian hosts and is caused by a range of different lineages of the Mycobacterium tuberculosis complex (MTBC). A recently described member, Mycobacterium suricattae, causes tuberculosis in meerkats (Suricata suricatta) in Southern Africa and preliminary genetic analysis showed this organism to be closely related to an MTBC pathogen of rock hyraxes (Procavia capensis), the dassie bacillus. Here we make use of whole genome sequencing to describe the evolution of the genome of M. suricattae, including known and novel regions of difference, SNPs and IS6110 insertion sites. We used genome-wide phylogenetic analysis to show that M. suricattae clusters with the chimpanzee bacillus, previously isolated from a chimpanzee (Pan troglodytes) in West Africa. We propose an evolutionary scenario for the Mycobacterium africanum lineage 6 complex, showing the evolutionary relationship of M. africanum and chimpanzee bacillus, and the closely related members M. suricattae, dassie bacillus and Mycobacterium mungi.

Original language	English (US)
Pages (from-to)	682-688
Number of pages	7
Journal	Tuberculosis
Volume	95
Issue number	6
DOIs	https://doi.org/10.1016/j.tube.2015.10.001
State	Published - Oct 21 2015

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This paper has relied on records of individual identities and/or life histories maintained by the Kalahari Meerkat Project, which has been supported by the European Research Council (Research Grant No. 294494 to T.H. Clutton-Brock since 1/7/2012) and the University of Zurich. This work was supported by the South African National Research Foundation (NRF), fund number 41744, South African Medical Research Council (MRC), Harry Crossley Foundation, Claude Leon Foundation, the Department of Biomedical Sciences, Stellenbosch University and King Abdullah University of Science and Technology (KAUST). S.L. Sampson is funded by the South African Research Chairs Initiative of the Department of Science and Technology and NRF of South Africa, award number UID 86539. Any opinion, finding and conclusion or recommendation expressed in this material is that of the author(s) and the NRF does not accept any liability in this regard.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tube.2015.10.001

Cite this

@article{d19977c6d4534b43a0c3e5490cfd6ae0,

title = "Whole genome sequence analysis of Mycobacterium suricattae",

abstract = "Tuberculosis occurs in various mammalian hosts and is caused by a range of different lineages of the Mycobacterium tuberculosis complex (MTBC). A recently described member, Mycobacterium suricattae, causes tuberculosis in meerkats (Suricata suricatta) in Southern Africa and preliminary genetic analysis showed this organism to be closely related to an MTBC pathogen of rock hyraxes (Procavia capensis), the dassie bacillus. Here we make use of whole genome sequencing to describe the evolution of the genome of M. suricattae, including known and novel regions of difference, SNPs and IS6110 insertion sites. We used genome-wide phylogenetic analysis to show that M. suricattae clusters with the chimpanzee bacillus, previously isolated from a chimpanzee (Pan troglodytes) in West Africa. We propose an evolutionary scenario for the Mycobacterium africanum lineage 6 complex, showing the evolutionary relationship of M. africanum and chimpanzee bacillus, and the closely related members M. suricattae, dassie bacillus and Mycobacterium mungi.",

author = "Anzaan Dippenaar and Parsons, {Sven David Charles} and Sampson, {Samantha Leigh} and {Van Der Merwe}, {Ruben Gerhard} and Drewe, {Julian Ashley} and Abdallah Abdallah and Siame, {Kabengele Keith} and {Gey Van Pittius}, {Nicolaas Claudius} and {Van Helden}, {Paul David} and Arnab Pain and Warren, {Robin Mark}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This paper has relied on records of individual identities and/or life histories maintained by the Kalahari Meerkat Project, which has been supported by the European Research Council (Research Grant No. 294494 to T.H. Clutton-Brock since 1/7/2012) and the University of Zurich. This work was supported by the South African National Research Foundation (NRF), fund number 41744, South African Medical Research Council (MRC), Harry Crossley Foundation, Claude Leon Foundation, the Department of Biomedical Sciences, Stellenbosch University and King Abdullah University of Science and Technology (KAUST). S.L. Sampson is funded by the South African Research Chairs Initiative of the Department of Science and Technology and NRF of South Africa, award number UID 86539. Any opinion, finding and conclusion or recommendation expressed in this material is that of the author(s) and the NRF does not accept any liability in this regard.",

year = "2015",

month = oct,

day = "21",

doi = "10.1016/j.tube.2015.10.001",

language = "English (US)",

volume = "95",

pages = "682--688",

journal = "Tuberculosis",

issn = "1472-9792",

publisher = "Churchill Livingstone",

number = "6",

}

TY - JOUR

T1 - Whole genome sequence analysis of Mycobacterium suricattae

AU - Dippenaar, Anzaan

AU - Parsons, Sven David Charles

AU - Sampson, Samantha Leigh

AU - Van Der Merwe, Ruben Gerhard

AU - Drewe, Julian Ashley

AU - Abdallah, Abdallah

AU - Siame, Kabengele Keith

AU - Gey Van Pittius, Nicolaas Claudius

AU - Van Helden, Paul David

AU - Pain, Arnab

AU - Warren, Robin Mark

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This paper has relied on records of individual identities and/or life histories maintained by the Kalahari Meerkat Project, which has been supported by the European Research Council (Research Grant No. 294494 to T.H. Clutton-Brock since 1/7/2012) and the University of Zurich. This work was supported by the South African National Research Foundation (NRF), fund number 41744, South African Medical Research Council (MRC), Harry Crossley Foundation, Claude Leon Foundation, the Department of Biomedical Sciences, Stellenbosch University and King Abdullah University of Science and Technology (KAUST). S.L. Sampson is funded by the South African Research Chairs Initiative of the Department of Science and Technology and NRF of South Africa, award number UID 86539. Any opinion, finding and conclusion or recommendation expressed in this material is that of the author(s) and the NRF does not accept any liability in this regard.

PY - 2015/10/21

Y1 - 2015/10/21

N2 - Tuberculosis occurs in various mammalian hosts and is caused by a range of different lineages of the Mycobacterium tuberculosis complex (MTBC). A recently described member, Mycobacterium suricattae, causes tuberculosis in meerkats (Suricata suricatta) in Southern Africa and preliminary genetic analysis showed this organism to be closely related to an MTBC pathogen of rock hyraxes (Procavia capensis), the dassie bacillus. Here we make use of whole genome sequencing to describe the evolution of the genome of M. suricattae, including known and novel regions of difference, SNPs and IS6110 insertion sites. We used genome-wide phylogenetic analysis to show that M. suricattae clusters with the chimpanzee bacillus, previously isolated from a chimpanzee (Pan troglodytes) in West Africa. We propose an evolutionary scenario for the Mycobacterium africanum lineage 6 complex, showing the evolutionary relationship of M. africanum and chimpanzee bacillus, and the closely related members M. suricattae, dassie bacillus and Mycobacterium mungi.

AB - Tuberculosis occurs in various mammalian hosts and is caused by a range of different lineages of the Mycobacterium tuberculosis complex (MTBC). A recently described member, Mycobacterium suricattae, causes tuberculosis in meerkats (Suricata suricatta) in Southern Africa and preliminary genetic analysis showed this organism to be closely related to an MTBC pathogen of rock hyraxes (Procavia capensis), the dassie bacillus. Here we make use of whole genome sequencing to describe the evolution of the genome of M. suricattae, including known and novel regions of difference, SNPs and IS6110 insertion sites. We used genome-wide phylogenetic analysis to show that M. suricattae clusters with the chimpanzee bacillus, previously isolated from a chimpanzee (Pan troglodytes) in West Africa. We propose an evolutionary scenario for the Mycobacterium africanum lineage 6 complex, showing the evolutionary relationship of M. africanum and chimpanzee bacillus, and the closely related members M. suricattae, dassie bacillus and Mycobacterium mungi.

UR - http://hdl.handle.net/10754/622349

UR - https://linkinghub.elsevier.com/retrieve/pii/S1472979215301712

UR - http://www.scopus.com/inward/record.url?scp=84948692815&partnerID=8YFLogxK

U2 - 10.1016/j.tube.2015.10.001

DO - 10.1016/j.tube.2015.10.001

M3 - Article

C2 - 26542221

SN - 1472-9792

VL - 95

SP - 682

EP - 688

JO - Tuberculosis

JF - Tuberculosis

IS - 6

ER -

Whole genome sequence analysis of Mycobacterium suricattae

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this