Well-defined cyclic polymer synthesis via an efficient etherification-based bimolecular ring-closure strategy

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The synthesis of cyclic polymers on a large scale is a challenging task for polymer scientists due to the requirement of ultra-high dilution conditions. In this paper, we demonstrate an alternative method to prepare cyclic polymers with moderate dilution and up to 1 gram scale. We employed a simple Williamson etherification reaction to prepare cyclic polymers with a good solvent/non-solvent combination. In this way, various polystyrene (PS) and polyethylene glycol (PEG) cyclic homopolymers were synthesized. Anionic polymerization using high vacuum techniques combined with the postpolymerization reaction was used to generate linear dihydroxy PS precursors. The synthesized linear and cyclic homopolymers were fully characterized using various spectroscopic and analytical techniques, such as size exclusion chromatography (SEC), matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF-MS), and differential scanning calorimetry (DSC). Detailed nuclear magnetic resonance (NMR) spectroscopic studies were also performed to obtain the complete structural information of the synthesized polymers.
Original languageEnglish (US)
StatePublished - Oct 28 2021

Bibliographical note

KAUST Repository Item: Exported on 2021-11-22
Acknowledgements: The research reported in this publication was supported by King Abdullah University of Science and Technology (KAUST).

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Biomedical Engineering
  • Bioengineering
  • Polymers and Plastics


Dive into the research topics of 'Well-defined cyclic polymer synthesis via an efficient etherification-based bimolecular ring-closure strategy'. Together they form a unique fingerprint.

Cite this