Water-soluble stimuli-responsive vesicles from peptide-based diblock copolymers

Frédéric Chécot; Sébastien Lecommandoux; Yves Gnanou; Harm Anton Klok

doi:10.1002/1521-3773(20020415)41:8<1339::AID-ANIE1339>3.0.CO;2-N

Water-soluble stimuli-responsive vesicles from peptide-based diblock copolymers

Frédéric Chécot, Sébastien Lecommandoux^*, Yves Gnanou, Harm Anton Klok

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

326 Scopus citations

Abstract

Polypeptide secondary structure controls the dimensions of aggregates formed from a polybutadieneb-poly(L-glutamic acid) diblock copolymer after direct dissolution into water. The hydrodynamic radius (R_H) of these aggregates (even at high NaCl concentrations) were found to correlate (see picture) with a transition from a compactly folded α-helical poly(L-glutamic acid) block at low pH to an extended random coil conformation at basic pH.

Original language	English (US)
Pages (from-to)	1339-1343
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	41
Issue number	8
DOIs	https://doi.org/10.1002/1521-3773(20020415)41:8<1339::AID-ANIE1339>3.0.CO;2-N
State	Published - Apr 15 2002
Externally published	Yes

Keywords

Amino acids
Copolymers
Nanostructures
Self-assembly
Vesicles

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/1521-3773(20020415)41:8<1339::AID-ANIE1339>3.0.CO;2-N

Cite this

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title = "Water-soluble stimuli-responsive vesicles from peptide-based diblock copolymers",

abstract = "Polypeptide secondary structure controls the dimensions of aggregates formed from a polybutadieneb-poly(L-glutamic acid) diblock copolymer after direct dissolution into water. The hydrodynamic radius (RH) of these aggregates (even at high NaCl concentrations) were found to correlate (see picture) with a transition from a compactly folded α-helical poly(L-glutamic acid) block at low pH to an extended random coil conformation at basic pH.",

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author = "Fr{\'e}d{\'e}ric Ch{\'e}cot and S{\'e}bastien Lecommandoux and Yves Gnanou and Klok, {Harm Anton}",

year = "2002",

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T1 - Water-soluble stimuli-responsive vesicles from peptide-based diblock copolymers

AU - Chécot, Frédéric

AU - Lecommandoux, Sébastien

AU - Gnanou, Yves

AU - Klok, Harm Anton

PY - 2002/4/15

Y1 - 2002/4/15

N2 - Polypeptide secondary structure controls the dimensions of aggregates formed from a polybutadieneb-poly(L-glutamic acid) diblock copolymer after direct dissolution into water. The hydrodynamic radius (RH) of these aggregates (even at high NaCl concentrations) were found to correlate (see picture) with a transition from a compactly folded α-helical poly(L-glutamic acid) block at low pH to an extended random coil conformation at basic pH.

AB - Polypeptide secondary structure controls the dimensions of aggregates formed from a polybutadieneb-poly(L-glutamic acid) diblock copolymer after direct dissolution into water. The hydrodynamic radius (RH) of these aggregates (even at high NaCl concentrations) were found to correlate (see picture) with a transition from a compactly folded α-helical poly(L-glutamic acid) block at low pH to an extended random coil conformation at basic pH.

KW - Amino acids

KW - Copolymers

KW - Nanostructures

KW - Self-assembly

KW - Vesicles

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U2 - 10.1002/1521-3773(20020415)41:8<1339::AID-ANIE1339>3.0.CO;2-N

DO - 10.1002/1521-3773(20020415)41:8<1339::AID-ANIE1339>3.0.CO;2-N

M3 - Article

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AN - SCOPUS:0037090933

SN - 1433-7851

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SP - 1339

EP - 1343

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 8

ER -

Water-soluble stimuli-responsive vesicles from peptide-based diblock copolymers

Abstract

Keywords

ASJC Scopus subject areas

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