Visible-Light Photoredox-Catalyzed Giese Reaction: Decarboxylative Addition of Amino Acid Derived α-Amino Radicals to Electron-Deficient Olefins

Anthony Millet, Quentin Lefebvre, Magnus Rueping

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87 Scopus citations

Abstract

A tin- and halide-free, visible-light photoredox-catalyzed Giese reaction was developed. Primary and secondary α-amino radicals were generated readily from amino acids in the presence of catalytic amounts of an iridium photocatalyst. The reactivity of the α-amino radicals has been evaluated for the functionalization of a variety of activated olefins. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Original languageEnglish (US)
Pages (from-to)13464-13468
Number of pages5
JournalChemistry - A European Journal
Volume22
Issue number38
DOIs
StatePublished - Jun 20 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: European Research Council

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