Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins

Junrui Zhang; Alexandra Vancea; Umar F. Shahul Hameed; Stefan T. Arold

doi:10.1016/j.csbj.2021.05.025

Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins

Junrui Zhang, Alexandra Vancea, Umar F. Shahul Hameed, Stefan T. Arold

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In plants, AAA-adenosine triphosphatase (ATPase) Cell Division Control Protein 48 (CDC48) uses the force generated through ATP hydrolysis to pull, extract, and unfold ubiquitylated or sumoylated proteins from the membrane, chromatin, or protein complexes. The resulting changes in protein or RNA content are an important means for plants to control protein homeostasis and thereby adapt to shifting environmental conditions. The activity and targeting of CDC48 are controlled by adaptor proteins, of which the plant ubiquitin regulatory X (UBX) domain-containing (PUX) proteins constitute the largest family. Emerging knowledge on the structure and function of PUX proteins highlights that these proteins are versatile factors for plant homeostasis and adaptation that might inspire biotechnological applications.

Original language	English (US)
Pages (from-to)	3125-3132
Number of pages	8
Journal	Computational and Structural Biotechnology Journal
Volume	19
DOIs	https://doi.org/10.1016/j.csbj.2021.05.025
State	Published - May 14 2021

Bibliographical note

KAUST Repository Item: Exported on 2021-06-09
Acknowledged KAUST grant number(s): URF/1/4039-01
Acknowledgements: This research was supported by the King Abdullah University of Science and Technology (KAUST) through the baseline fund and the Award No. URF/1/4039-01 from the Office of Sponsored Research (OSR). We thank I. Blilou for comments on the manuscript.

ASJC Scopus subject areas

Biophysics
Biotechnology
Genetics
Biochemistry
Structural Biology
Computer Science Applications

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10.1016/j.csbj.2021.05.025

https://repository.kaust.edu.sa/bitstream/10754/669443/1/1-s2.0-S2001037021002063-main.pdf

Cite this

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title = "Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins",

abstract = "In plants, AAA-adenosine triphosphatase (ATPase) Cell Division Control Protein 48 (CDC48) uses the force generated through ATP hydrolysis to pull, extract, and unfold ubiquitylated or sumoylated proteins from the membrane, chromatin, or protein complexes. The resulting changes in protein or RNA content are an important means for plants to control protein homeostasis and thereby adapt to shifting environmental conditions. The activity and targeting of CDC48 are controlled by adaptor proteins, of which the plant ubiquitin regulatory X (UBX) domain-containing (PUX) proteins constitute the largest family. Emerging knowledge on the structure and function of PUX proteins highlights that these proteins are versatile factors for plant homeostasis and adaptation that might inspire biotechnological applications.",

author = "Junrui Zhang and Alexandra Vancea and {Shahul Hameed}, {Umar F.} and Arold, {Stefan T.}",

note = "KAUST Repository Item: Exported on 2021-06-09 Acknowledged KAUST grant number(s): URF/1/4039-01 Acknowledgements: This research was supported by the King Abdullah University of Science and Technology (KAUST) through the baseline fund and the Award No. URF/1/4039-01 from the Office of Sponsored Research (OSR). We thank I. Blilou for comments on the manuscript.",

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doi = "10.1016/j.csbj.2021.05.025",

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AU - Zhang, Junrui

AU - Vancea, Alexandra

AU - Shahul Hameed, Umar F.

AU - Arold, Stefan T.

N1 - KAUST Repository Item: Exported on 2021-06-09 Acknowledged KAUST grant number(s): URF/1/4039-01 Acknowledgements: This research was supported by the King Abdullah University of Science and Technology (KAUST) through the baseline fund and the Award No. URF/1/4039-01 from the Office of Sponsored Research (OSR). We thank I. Blilou for comments on the manuscript.

PY - 2021/5/14

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N2 - In plants, AAA-adenosine triphosphatase (ATPase) Cell Division Control Protein 48 (CDC48) uses the force generated through ATP hydrolysis to pull, extract, and unfold ubiquitylated or sumoylated proteins from the membrane, chromatin, or protein complexes. The resulting changes in protein or RNA content are an important means for plants to control protein homeostasis and thereby adapt to shifting environmental conditions. The activity and targeting of CDC48 are controlled by adaptor proteins, of which the plant ubiquitin regulatory X (UBX) domain-containing (PUX) proteins constitute the largest family. Emerging knowledge on the structure and function of PUX proteins highlights that these proteins are versatile factors for plant homeostasis and adaptation that might inspire biotechnological applications.

AB - In plants, AAA-adenosine triphosphatase (ATPase) Cell Division Control Protein 48 (CDC48) uses the force generated through ATP hydrolysis to pull, extract, and unfold ubiquitylated or sumoylated proteins from the membrane, chromatin, or protein complexes. The resulting changes in protein or RNA content are an important means for plants to control protein homeostasis and thereby adapt to shifting environmental conditions. The activity and targeting of CDC48 are controlled by adaptor proteins, of which the plant ubiquitin regulatory X (UBX) domain-containing (PUX) proteins constitute the largest family. Emerging knowledge on the structure and function of PUX proteins highlights that these proteins are versatile factors for plant homeostasis and adaptation that might inspire biotechnological applications.

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SN - 2001-0370

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SP - 3125

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JO - Computational and Structural Biotechnology Journal

JF - Computational and Structural Biotechnology Journal

ER -

Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins

Abstract

Bibliographical note

ASJC Scopus subject areas

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