Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins

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7 Scopus citations


In plants, AAA-adenosine triphosphatase (ATPase) Cell Division Control Protein 48 (CDC48) uses the force generated through ATP hydrolysis to pull, extract, and unfold ubiquitylated or sumoylated proteins from the membrane, chromatin, or protein complexes. The resulting changes in protein or RNA content are an important means for plants to control protein homeostasis and thereby adapt to shifting environmental conditions. The activity and targeting of CDC48 are controlled by adaptor proteins, of which the plant ubiquitin regulatory X (UBX) domain-containing (PUX) proteins constitute the largest family. Emerging knowledge on the structure and function of PUX proteins highlights that these proteins are versatile factors for plant homeostasis and adaptation that might inspire biotechnological applications.
Original languageEnglish (US)
Pages (from-to)3125-3132
Number of pages8
JournalComputational and Structural Biotechnology Journal
StatePublished - May 14 2021

Bibliographical note

KAUST Repository Item: Exported on 2021-06-09
Acknowledged KAUST grant number(s): URF/1/4039-01
Acknowledgements: This research was supported by the King Abdullah University of Science and Technology (KAUST) through the baseline fund and the Award No. URF/1/4039-01 from the Office of Sponsored Research (OSR). We thank I. Blilou for comments on the manuscript.

ASJC Scopus subject areas

  • Biophysics
  • Biotechnology
  • Genetics
  • Biochemistry
  • Structural Biology
  • Computer Science Applications


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