Unactivated Alkyl Chloride Reactivity in Excited-State Palladium Catalysis

Krishnamoorthy Muralirajan, Rajesh Kancherla, Aidana Gimnkhan, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Excited-state palladium catalysis is an efficient process for the alkylation of diverse organic compounds via the generation of alkyl radicals from alkyl bromides and iodides. However, the generation of alkyl radicals from more stable alkyl chlorides remains challenging. Herein, we demonstrate the excited-state palladium-catalyzed synthesis of oxindoles and isoquinolinediones via alkylation/annulation reaction by overcoming inherent limitations associated with unactivated C(sp3)-Cl bond activation at room temperature.
Original languageEnglish (US)
JournalOrganic Letters
DOIs
StatePublished - Aug 25 2021

Bibliographical note

KAUST Repository Item: Exported on 2021-08-31
Acknowledged KAUST grant number(s): URF/1/4025
Acknowledgements: We acknowledge King Abdullah University of Science and Technology (KAUST) for support. This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (URF/1/4025).

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry

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