Ultrathin Two-Dimensional Covalent Organic Framework Nanosheets: Preparation and Application in Highly Sensitive and Selective DNA Detection

Yongwu Peng; Ying Huang; Yihan Zhu; Bo Chen; Liying Wang; Zhuangchai Lai; Zhicheng Zhang; Meiting Zhao; Chaoliang Tan; Nailiang Yang; Fangwei Shao; Yu Han; Hua Zhang

doi:10.1021/jacs.7b04096

Ultrathin Two-Dimensional Covalent Organic Framework Nanosheets: Preparation and Application in Highly Sensitive and Selective DNA Detection

Yongwu Peng, Ying Huang, Yihan Zhu, Bo Chen, Liying Wang, Zhuangchai Lai, Zhicheng Zhang, Meiting Zhao, Chaoliang Tan, Nailiang Yang, Fangwei Shao, Yu Han, Hua Zhang

Research output: Contribution to journal › Article › peer-review

465 Scopus citations

Abstract

The ability to prepare ultrathin two-dimensional (2D) covalent organic framework (COF) nanosheets (NSs) in high yield is of great importance for the further exploration of their unique properties and potential applications. Herein, by elaborately designing and choosing two flexible molecules with C3v molecular symmetry as building units, a novel imine-linked COF, namely TPA-COF, with hexagonal layered structure and sheet-like morphology, is synthesized. Since the flexible building units are integrated into the COF skeletons, the interlayer stacking becomes weak, resulting in the easy exfoliation of TPA-COF into ultrathin 2D NSs. Impressively, for the first time, the detailed structural information, i.e. the pore channels and individual building units in the NSs, is clearly visualized by using the recently developed low-dose imaging technique of transmission electron microscopy (TEM). As a proof-of-concept application, the obtained ultrathin COF NSs are used as a novel fluorescence sensing platform for the highly sensitive and selective detection of DNA.

Original language	English (US)
Pages (from-to)	8698-8704
Number of pages	7
Journal	Journal of the American Chemical Society
Volume	139
Issue number	25
DOIs	https://doi.org/10.1021/jacs.7b04096
State	Published - Jun 15 2017

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by MOE under AcRF Tier 2 (ARC 19/15, No. MOE2014-T2-2-093; MOE2015-T2-2-057; MOE2016-T2-2-103) and AcRF Tier 1 (2016-T1-001-147; 2016-T1-002-051), NTU under Start-Up Grant (M4081296.070.500000) and iFood Research Grant (M4081458.070.500000), and Singapore Millennium Foundation in Singapore. We would like to acknowledge the Facility for Analysis, Characterization, Testing and Simulation, Nanyang Technological University, Singapore, for use of their electron microscopy facilities.

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10.1021/jacs.7b04096

https://repository.kaust.edu.sa/bitstream/10754/624891/1/jacs2E7b04096.pdf

Cite this

Peng, Y., Huang, Y., Zhu, Y., Chen, B., Wang, L., Lai, Z., Zhang, Z., Zhao, M., Tan, C., Yang, N., Shao, F., Han, Y., & Zhang, H. (2017). Ultrathin Two-Dimensional Covalent Organic Framework Nanosheets: Preparation and Application in Highly Sensitive and Selective DNA Detection. Journal of the American Chemical Society, 139(25), 8698-8704. https://doi.org/10.1021/jacs.7b04096

@article{d274e3e239fe4cfe80074e28cb68457f,

title = "Ultrathin Two-Dimensional Covalent Organic Framework Nanosheets: Preparation and Application in Highly Sensitive and Selective DNA Detection",

abstract = "The ability to prepare ultrathin two-dimensional (2D) covalent organic framework (COF) nanosheets (NSs) in high yield is of great importance for the further exploration of their unique properties and potential applications. Herein, by elaborately designing and choosing two flexible molecules with C3v molecular symmetry as building units, a novel imine-linked COF, namely TPA-COF, with hexagonal layered structure and sheet-like morphology, is synthesized. Since the flexible building units are integrated into the COF skeletons, the interlayer stacking becomes weak, resulting in the easy exfoliation of TPA-COF into ultrathin 2D NSs. Impressively, for the first time, the detailed structural information, i.e. the pore channels and individual building units in the NSs, is clearly visualized by using the recently developed low-dose imaging technique of transmission electron microscopy (TEM). As a proof-of-concept application, the obtained ultrathin COF NSs are used as a novel fluorescence sensing platform for the highly sensitive and selective detection of DNA.",

author = "Yongwu Peng and Ying Huang and Yihan Zhu and Bo Chen and Liying Wang and Zhuangchai Lai and Zhicheng Zhang and Meiting Zhao and Chaoliang Tan and Nailiang Yang and Fangwei Shao and Yu Han and Hua Zhang",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by MOE under AcRF Tier 2 (ARC 19/15, No. MOE2014-T2-2-093; MOE2015-T2-2-057; MOE2016-T2-2-103) and AcRF Tier 1 (2016-T1-001-147; 2016-T1-002-051), NTU under Start-Up Grant (M4081296.070.500000) and iFood Research Grant (M4081458.070.500000), and Singapore Millennium Foundation in Singapore. We would like to acknowledge the Facility for Analysis, Characterization, Testing and Simulation, Nanyang Technological University, Singapore, for use of their electron microscopy facilities.",

year = "2017",

month = jun,

day = "15",

doi = "10.1021/jacs.7b04096",

language = "English (US)",

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Peng, Y, Huang, Y, Zhu, Y, Chen, B, Wang, L, Lai, Z, Zhang, Z, Zhao, M, Tan, C, Yang, N, Shao, F, Han, Y & Zhang, H 2017, 'Ultrathin Two-Dimensional Covalent Organic Framework Nanosheets: Preparation and Application in Highly Sensitive and Selective DNA Detection', Journal of the American Chemical Society, vol. 139, no. 25, pp. 8698-8704. https://doi.org/10.1021/jacs.7b04096

TY - JOUR

T1 - Ultrathin Two-Dimensional Covalent Organic Framework Nanosheets: Preparation and Application in Highly Sensitive and Selective DNA Detection

AU - Peng, Yongwu

AU - Huang, Ying

AU - Zhu, Yihan

AU - Chen, Bo

AU - Wang, Liying

AU - Lai, Zhuangchai

AU - Zhang, Zhicheng

AU - Zhao, Meiting

AU - Tan, Chaoliang

AU - Yang, Nailiang

AU - Shao, Fangwei

AU - Han, Yu

AU - Zhang, Hua

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by MOE under AcRF Tier 2 (ARC 19/15, No. MOE2014-T2-2-093; MOE2015-T2-2-057; MOE2016-T2-2-103) and AcRF Tier 1 (2016-T1-001-147; 2016-T1-002-051), NTU under Start-Up Grant (M4081296.070.500000) and iFood Research Grant (M4081458.070.500000), and Singapore Millennium Foundation in Singapore. We would like to acknowledge the Facility for Analysis, Characterization, Testing and Simulation, Nanyang Technological University, Singapore, for use of their electron microscopy facilities.

PY - 2017/6/15

Y1 - 2017/6/15

N2 - The ability to prepare ultrathin two-dimensional (2D) covalent organic framework (COF) nanosheets (NSs) in high yield is of great importance for the further exploration of their unique properties and potential applications. Herein, by elaborately designing and choosing two flexible molecules with C3v molecular symmetry as building units, a novel imine-linked COF, namely TPA-COF, with hexagonal layered structure and sheet-like morphology, is synthesized. Since the flexible building units are integrated into the COF skeletons, the interlayer stacking becomes weak, resulting in the easy exfoliation of TPA-COF into ultrathin 2D NSs. Impressively, for the first time, the detailed structural information, i.e. the pore channels and individual building units in the NSs, is clearly visualized by using the recently developed low-dose imaging technique of transmission electron microscopy (TEM). As a proof-of-concept application, the obtained ultrathin COF NSs are used as a novel fluorescence sensing platform for the highly sensitive and selective detection of DNA.

AB - The ability to prepare ultrathin two-dimensional (2D) covalent organic framework (COF) nanosheets (NSs) in high yield is of great importance for the further exploration of their unique properties and potential applications. Herein, by elaborately designing and choosing two flexible molecules with C3v molecular symmetry as building units, a novel imine-linked COF, namely TPA-COF, with hexagonal layered structure and sheet-like morphology, is synthesized. Since the flexible building units are integrated into the COF skeletons, the interlayer stacking becomes weak, resulting in the easy exfoliation of TPA-COF into ultrathin 2D NSs. Impressively, for the first time, the detailed structural information, i.e. the pore channels and individual building units in the NSs, is clearly visualized by using the recently developed low-dose imaging technique of transmission electron microscopy (TEM). As a proof-of-concept application, the obtained ultrathin COF NSs are used as a novel fluorescence sensing platform for the highly sensitive and selective detection of DNA.

UR - http://hdl.handle.net/10754/624891

UR - http://pubs.acs.org/doi/abs/10.1021/jacs.7b04096

UR - http://www.scopus.com/inward/record.url?scp=85021656960&partnerID=8YFLogxK

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DO - 10.1021/jacs.7b04096

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VL - 139

SP - 8698

EP - 8704

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 25

ER -

Ultrathin Two-Dimensional Covalent Organic Framework Nanosheets: Preparation and Application in Highly Sensitive and Selective DNA Detection

Abstract

Bibliographical note

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CCDC 1556937: Experimental Crystal Structure Determination : poly-(tris(4-(iminomethyl)phenyl)amine)

CCDC 1556938: Experimental Crystal Structure Determination : poly-(tris(4-(iminomethyl)phenyl)amine)

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Ultrathin Two-Dimensional Covalent Organic Framework Nanosheets: Preparation and Application in Highly Sensitive and Selective DNA Detection

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Datasets

CCDC 1556937: Experimental Crystal Structure Determination : poly-(tris(4-(iminomethyl)phenyl)amine)

CCDC 1556938: Experimental Crystal Structure Determination : poly-(tris(4-(iminomethyl)phenyl)amine)

Cite this