TY - JOUR
T1 - Type VII secretion - Mycobacteria show the way
AU - Abdallah, Abdallah
AU - Gey van Pittius, Nicolaas C.
AU - DiGiuseppe Champion, Patricia A.
AU - Cox, Jeffery
AU - Luirink, Joen
AU - Vandenbroucke-Grauls, Christina M J E
AU - Appelmelk, Ben J.
AU - Bitter, Wilbert
PY - 2007/11/1
Y1 - 2007/11/1
N2 - Recent evidence shows that mycobacteria have developed novel and specialized secretion systems for the transport of extracellular proteins across their hydrophobic, and highly impermeable, cell wall. Strikingly, mycobacterial genomes encode up to five of these transport systems. Two of these systems, ESX-1 and ESX-5, are involved in virulence - they both affect the cell-to-cell migration of pathogenic mycobacteria. Here, we discuss this novel secretion pathway and consider variants that are present in various Gram-positive bacteria. Given the unique composition of this secretion system, and its general importance, we propose that, in line with the accepted nomenclature, it should be called type VII secretion.
AB - Recent evidence shows that mycobacteria have developed novel and specialized secretion systems for the transport of extracellular proteins across their hydrophobic, and highly impermeable, cell wall. Strikingly, mycobacterial genomes encode up to five of these transport systems. Two of these systems, ESX-1 and ESX-5, are involved in virulence - they both affect the cell-to-cell migration of pathogenic mycobacteria. Here, we discuss this novel secretion pathway and consider variants that are present in various Gram-positive bacteria. Given the unique composition of this secretion system, and its general importance, we propose that, in line with the accepted nomenclature, it should be called type VII secretion.
UR - http://www.scopus.com/inward/record.url?scp=35348892037&partnerID=8YFLogxK
U2 - 10.1038/nrmicro1773
DO - 10.1038/nrmicro1773
M3 - Article
C2 - 17922044
AN - SCOPUS:35348892037
SN - 1740-1526
VL - 5
SP - 883
EP - 891
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 11
ER -