Type VII secretion - Mycobacteria show the way

Abdallah M. Abdallah; Nicolaas C. Gey van Pittius; Patricia A. DiGiuseppe Champion; Jeffery Cox; Joen Luirink; Christina M.J.E. Vandenbroucke-Grauls; Ben J. Appelmelk; Wilbert Bitter

doi:10.1038/nrmicro1773

Type VII secretion - Mycobacteria show the way

Abdallah M. Abdallah^*, Nicolaas C. Gey van Pittius, Patricia A. DiGiuseppe Champion, Jeffery Cox, Joen Luirink, Christina M.J.E. Vandenbroucke-Grauls, Ben J. Appelmelk, Wilbert Bitter

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

577 Scopus citations

Abstract

Recent evidence shows that mycobacteria have developed novel and specialized secretion systems for the transport of extracellular proteins across their hydrophobic, and highly impermeable, cell wall. Strikingly, mycobacterial genomes encode up to five of these transport systems. Two of these systems, ESX-1 and ESX-5, are involved in virulence - they both affect the cell-to-cell migration of pathogenic mycobacteria. Here, we discuss this novel secretion pathway and consider variants that are present in various Gram-positive bacteria. Given the unique composition of this secretion system, and its general importance, we propose that, in line with the accepted nomenclature, it should be called type VII secretion.

Original language	English (US)
Pages (from-to)	883-891
Number of pages	9
Journal	Nature Reviews Microbiology
Volume	5
Issue number	11
DOIs	https://doi.org/10.1038/nrmicro1773
State	Published - Nov 2007
Externally published	Yes

ASJC Scopus subject areas

General Immunology and Microbiology
Infectious Diseases
Microbiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrmicro1773

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title = "Type VII secretion - Mycobacteria show the way",

abstract = "Recent evidence shows that mycobacteria have developed novel and specialized secretion systems for the transport of extracellular proteins across their hydrophobic, and highly impermeable, cell wall. Strikingly, mycobacterial genomes encode up to five of these transport systems. Two of these systems, ESX-1 and ESX-5, are involved in virulence - they both affect the cell-to-cell migration of pathogenic mycobacteria. Here, we discuss this novel secretion pathway and consider variants that are present in various Gram-positive bacteria. Given the unique composition of this secretion system, and its general importance, we propose that, in line with the accepted nomenclature, it should be called type VII secretion.",

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AU - Abdallah, Abdallah M.

AU - Gey van Pittius, Nicolaas C.

AU - DiGiuseppe Champion, Patricia A.

AU - Cox, Jeffery

AU - Luirink, Joen

AU - Vandenbroucke-Grauls, Christina M.J.E.

AU - Appelmelk, Ben J.

AU - Bitter, Wilbert

PY - 2007/11

Y1 - 2007/11

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AB - Recent evidence shows that mycobacteria have developed novel and specialized secretion systems for the transport of extracellular proteins across their hydrophobic, and highly impermeable, cell wall. Strikingly, mycobacterial genomes encode up to five of these transport systems. Two of these systems, ESX-1 and ESX-5, are involved in virulence - they both affect the cell-to-cell migration of pathogenic mycobacteria. Here, we discuss this novel secretion pathway and consider variants that are present in various Gram-positive bacteria. Given the unique composition of this secretion system, and its general importance, we propose that, in line with the accepted nomenclature, it should be called type VII secretion.

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JO - Nature Reviews Microbiology

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Type VII secretion - Mycobacteria show the way

Abstract

ASJC Scopus subject areas

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