Two domain-disrupted hda6 alleles have opposite epigenetic effects on transgenes and some endogenous targets

ShouDong Zhang; Xiangqiang Zhan; Xiaoming Xu; Peng Cui; Jian-Kang Zhu; Yiji Xia; Liming Xiong

doi:10.1038/srep17832

Two domain-disrupted hda6 alleles have opposite epigenetic effects on transgenes and some endogenous targets

ShouDong Zhang, Xiangqiang Zhan, Xiaoming Xu, Peng Cui, Jian-Kang Zhu, Yiji Xia, Liming Xiong

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Abstract

HDA6 is a RPD3-like histone deacetylase. In Arabidopsis, it mediates transgene and some endogenous target transcriptional gene silencing (TGS) via histone deacetylation and DNA methylation. Here, we characterized two hda6 mutant alleles that were recovered as second-site suppressors of the DNA demethylation mutant ros1–1. Although both alleles derepressed 35S

Original language	English (US)
Journal	Scientific Reports
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/srep17832
State	Published - Dec 15 2015

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https://repository.kaust.edu.sa/bitstream/10754/592607/1/srep17832.pdf

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abstract = "HDA6 is a RPD3-like histone deacetylase. In Arabidopsis, it mediates transgene and some endogenous target transcriptional gene silencing (TGS) via histone deacetylation and DNA methylation. Here, we characterized two hda6 mutant alleles that were recovered as second-site suppressors of the DNA demethylation mutant ros1–1. Although both alleles derepressed 35S",

author = "ShouDong Zhang and Xiangqiang Zhan and Xiaoming Xu and Peng Cui and Jian-Kang Zhu and Yiji Xia and Liming Xiong",

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AU - Zhang, ShouDong

AU - Zhan, Xiangqiang

AU - Xu, Xiaoming

AU - Cui, Peng

AU - Zhu, Jian-Kang

AU - Xia, Yiji

AU - Xiong, Liming

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PY - 2015/12/15

Y1 - 2015/12/15

N2 - HDA6 is a RPD3-like histone deacetylase. In Arabidopsis, it mediates transgene and some endogenous target transcriptional gene silencing (TGS) via histone deacetylation and DNA methylation. Here, we characterized two hda6 mutant alleles that were recovered as second-site suppressors of the DNA demethylation mutant ros1–1. Although both alleles derepressed 35S

AB - HDA6 is a RPD3-like histone deacetylase. In Arabidopsis, it mediates transgene and some endogenous target transcriptional gene silencing (TGS) via histone deacetylation and DNA methylation. Here, we characterized two hda6 mutant alleles that were recovered as second-site suppressors of the DNA demethylation mutant ros1–1. Although both alleles derepressed 35S

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UR - http://www.nature.com/articles/srep17832

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ER -

Two domain-disrupted hda6 alleles have opposite epigenetic effects on transgenes and some endogenous targets

Abstract

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