Tumor-Associated-Macrophage-Membrane-Coated Nanoparticles for Improved Photodynamic Immunotherapy

Cailing Chen, Meiyu Song, Yangyang Du, Ying Yu, Chunguang Li, Yu Han, Fei Yan, Zhan Shi, Shouhua Feng

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


Cell-membrane-coated nanoparticles have emerged as a promising antitumor therapeutic strategy. However, the immunologic mechanism remains elusive, and there are still crucial issues to be addressed including tumor-homing capacity, immune incompatibility, and immunogenicity. Here, we reported a tumor-associated macrophage membrane (TAMM) derived from the primary tumor with unique antigen-homing affinity capacity and immune compatibility. TAMM could deplete the CSF1 secreted by tumor cells in the tumor microenvironment (TME), blocking the interaction between TAM and cancer cells. Especially, after coating TAMM to upconversion nanoparticle with conjugated photosensitizer (NPR@TAMM), NPR@TAMM-mediated photodynamic immunotherapy switched the activation of macrophages from an immunosuppressive M2-like phenotype to a more inflammatory M1-like state, induced immunogenic cell death, and consequently enhanced the antitumor immunity efficiency via activation of antigen-presenting cells to stimulate the production of tumor-specific effector T cells in metastatic tumors. This TAM-membrane-based photodynamic immunotherapy approach offers a new strategy for personalized tumor therapy.
Original languageEnglish (US)
JournalNano Letters
StatePublished - Jun 16 2021

Bibliographical note

KAUST Repository Item: Exported on 2021-06-18
Acknowledgements: This work was supported by the National Natural Science Foundation of China (NSFC; nos. 81870117, 91959201, 21771077, 21771084, and 21621001), the National Key Research and Development Program of China (no. 2016YFB0701100), the 111 project (no. B17020), and the Jilin Province Science and Technology Development Plan (20190201252JC). The authors also gratefully acknowledge the financial support by Program for JLU Science and Technology Innovative Research Team (JLUSTIRT).

ASJC Scopus subject areas

  • Bioengineering
  • General Materials Science
  • General Chemistry
  • Mechanical Engineering
  • Condensed Matter Physics


Dive into the research topics of 'Tumor-Associated-Macrophage-Membrane-Coated Nanoparticles for Improved Photodynamic Immunotherapy'. Together they form a unique fingerprint.

Cite this