Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

Carlotta Granchi; Sarabindu Roy; Claudia Del Fiandra; Tiziano Tuccinardi; Mario Lanza; Laura Betti; Gino Giannaccini; Antonio Lucacchini; Adriano Martinelli; Marco MacChia; Filippo Minutolo

doi:10.1039/c1md00071c

Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

Carlotta Granchi, Sarabindu Roy, Claudia Del Fiandra, Tiziano Tuccinardi, Mario Lanza, Laura Betti, Gino Giannaccini, Antonio Lucacchini, Adriano Martinelli, Marco MacChia, Filippo Minutolo^*

^*Corresponding author for this work

Physical Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

hLDH5 plays a key role in the glycolytic metabolic switch found in invasive tumours and is now considered as a promising therapeutic target in cancer. Here we report a series of new hLDH5-inhibitors based on triazole-containing N-hydroxyindol-2-carboxylates, whose synthesis includes the highly reliable and simple "click chemistry" reaction.

Original language	English (US)
Pages (from-to)	638-643
Number of pages	6
Journal	MedChemComm
Volume	2
Issue number	7
DOIs	https://doi.org/10.1039/c1md00071c
State	Published - Jul 2011

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c1md00071c

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abstract = "hLDH5 plays a key role in the glycolytic metabolic switch found in invasive tumours and is now considered as a promising therapeutic target in cancer. Here we report a series of new hLDH5-inhibitors based on triazole-containing N-hydroxyindol-2-carboxylates, whose synthesis includes the highly reliable and simple {"}click chemistry{"} reaction.",

author = "Carlotta Granchi and Sarabindu Roy and {Del Fiandra}, Claudia and Tiziano Tuccinardi and Mario Lanza and Laura Betti and Gino Giannaccini and Antonio Lucacchini and Adriano Martinelli and Marco MacChia and Filippo Minutolo",

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T1 - Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

AU - Granchi, Carlotta

AU - Roy, Sarabindu

AU - Del Fiandra, Claudia

AU - Tuccinardi, Tiziano

AU - Lanza, Mario

AU - Betti, Laura

AU - Giannaccini, Gino

AU - Lucacchini, Antonio

AU - Martinelli, Adriano

AU - MacChia, Marco

AU - Minutolo, Filippo

PY - 2011/7

Y1 - 2011/7

N2 - hLDH5 plays a key role in the glycolytic metabolic switch found in invasive tumours and is now considered as a promising therapeutic target in cancer. Here we report a series of new hLDH5-inhibitors based on triazole-containing N-hydroxyindol-2-carboxylates, whose synthesis includes the highly reliable and simple "click chemistry" reaction.

AB - hLDH5 plays a key role in the glycolytic metabolic switch found in invasive tumours and is now considered as a promising therapeutic target in cancer. Here we report a series of new hLDH5-inhibitors based on triazole-containing N-hydroxyindol-2-carboxylates, whose synthesis includes the highly reliable and simple "click chemistry" reaction.

UR - http://www.scopus.com/inward/record.url?scp=79960160604&partnerID=8YFLogxK

U2 - 10.1039/c1md00071c

DO - 10.1039/c1md00071c

M3 - Article

AN - SCOPUS:79960160604

SN - 2040-2503

VL - 2

SP - 638

EP - 643

JO - MedChemComm

JF - MedChemComm

IS - 7

ER -

Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)

Abstract

ASJC Scopus subject areas

UN SDGs

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