Translational and post-translational regulation of polyamine metabolic enzymes in plants.

J F Jiménez-Bremont, A I Chávez-Martínez, M A Ortega-Amaro, M L Guerrero-González, F I Jasso-Robles, Israel Maruri Lopez, Ji-Hong Liu, Sarvajeet Singh Gill, M Rodríguez-Kessler

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Polyamines are small organic and basic polycations that perform essential regulatory functions in all living organisms. Fluctuations in polyamine content have been observed to occur during growth, development and under stress conditions, implying that polyamines play pivotal roles in diverse cellular and physiological processes. To achieve polyamine homeostasis, the entire metabolic pathway is subjected to a fine-tuned regulation of its biosynthetic and catabolic genes and enzymes. In this review, we describe and discuss the most important mechanisms implicated in the translational and post-translational regulation of polyamine metabolic enzymes in plants. At the translational level, we emphasize the role of polyamines in the modulation of upstream open reading frame (uORF) activities that control the translation of polyamine biosynthetic and catabolic mRNAs. At the post-translational level, different aspects of the regulation of polyamine metabolic proteins are depicted, such as the proteolytic activation of enzyme precursors, the importance of dimerization in protein stability as well as in protein intracellular localization.
Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of Biotechnology
Volume344
DOIs
StatePublished - Dec 16 2021

Bibliographical note

KAUST Repository Item: Exported on 2022-01-27
Acknowledgements: This study was financed by Investigación Ciencia Básica CONACYT-México (2015-256574; 2017-2018-A1-S-25233), Ciencia de Frontera CONACYT-México (2019-1564453), National Key Research and Development Program of China (2018YFD1000302) and the National Natural Science Foundation of China (31772273). We apologize to those colleagues whose relevant work were not cited due to space constraints. We thank to Dr. Michael Frederick Dunn for his critical and grammatical review.

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Biotechnology

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