Transcription factor PIF4 controls the thermosensory activation of flowering

S. Vinod Kumar, Doris Lucyshyn, Katja E. Jaeger, Enriqueta Alós, Elizabeth Alvey, Nicholas P. Harberd, Philip A. Wigge

Research output: Contribution to journalArticlepeer-review

544 Scopus citations


Plant growth and development are strongly affected by small differences in temperature. Current climate change has already altered global plant phenology and distribution, and projected increases in temperature pose a significant challenge to agriculture. Despite the important role of temperature on plant development, the underlying pathways are unknown. It has previously been shown that thermal acceleration of flowering is dependent on the florigen, FLOWERING LOCUS T (FT). How this occurs is, however, not understood, because the major pathway known to upregulate FT, the photoperiod pathway, is not required for thermal acceleration of flowering. Here we demonstrate a direct mechanism by which increasing temperature causes the bHLH transcription factor PHYTOCHROME INTERACTING FACTOR4 (PIF4) to activate FT. Our findings provide a new understanding of how plants control their timing of reproduction in response to temperature. Flowering time is an important trait in crops as well as affecting the life cycles of pollinator species. A molecular understanding of how temperature affects flowering will be important for mitigating the effects of climate change. © 2012 Macmillan Publishers Limited. All rights reserved.
Original languageEnglish (US)
Pages (from-to)242-245
Number of pages4
Issue number7393
StatePublished - Mar 21 2012
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): KUK-I1-002-03
Acknowledgements: We thank S. Prat, C. Fankhauser, K. Franklin, K. Goto, G. Coupland and D. Weigel for seeds. We are grateful to members of the Wigge laboratory for discussions. This work was supported in part by award No. KUK-I1-002-03 (to N.P.H.) made by King Abdullah University of Science and Technology and a Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/I019022/1 (to S.V.K.). D.L. was supported by an Erwin Schroedinger Fellowship from the Austrian Science Fund FWF. P.A.W. was supported by start-up funds from the John Innes Centre and BBSRC, a BBSRC grant (BB/D0100470/1) and a European Research Council Starting Grant (ERC 243140).
This publication acknowledges KAUST support, but has no KAUST affiliated authors.


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