TP atlas: Integration and dissemination of advances in Targeted Proteins Research Program (TPRP)-structural biology project phase II in Japan

Takao Iwayanagi; Sei Miyamoto; Takeshi Konno; Hisashi Mizutani; Tomohiro Hirai; Yasumasa Shigemoto; Takashi Gojobori; Hideaki Sugawara

doi:10.1007/s10969-012-9139-1

TP atlas: Integration and dissemination of advances in Targeted Proteins Research Program (TPRP)-structural biology project phase II in Japan

Takao Iwayanagi^*, Sei Miyamoto, Takeshi Konno, Hisashi Mizutani, Tomohiro Hirai, Yasumasa Shigemoto, Takashi Gojobori, Hideaki Sugawara

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The Targeted Proteins Research Program (TPRP) promoted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan is the phase II of structural biology project (2007-2011) following the Protein 3000 Project (2002-2006) in Japan. While the phase I Protein 3000 Project put partial emphasis on the construction and maintenance of pipelines for structural analyses, the TPRP is dedicated to revealing the structures and functions of the targeted proteins that have great importance in both basic research and industrial applications. To pursue this objective, 35 Targeted Proteins (TP) Projects selected in the three areas of fundamental biology, medicine and pharmacology, and food and environment are tightly collaborated with 10 Advanced Technology (AT) Projects in the four fields of protein production, structural analyses, chemical library and screening, and information platform. Here, the outlines and achievements of the 35 TP Projects are summarized in the system named TP Atlas. Progress in the diversified areas is described in the modules of Graphical Summary, General Summary, Tabular Summary, and Structure Gallery of the TP Atlas in the standard and unified format. Advances in TP Projects owing to novel technologies stemmed from AT Projects and collaborative research among TP Projects are illustrated as a hallmark of the Program. The TP Atlas can be accessed at http://net.genes.nig.ac.jp/tpatlas/index-e.html .

Original language	English (US)
Pages (from-to)	145-154
Number of pages	10
Journal	Journal of Structural and Functional Genomics
Volume	13
Issue number	3
DOIs	https://doi.org/10.1007/s10969-012-9139-1
State	Published - Sep 2012
Externally published	Yes

Bibliographical note

Funding Information:
Structural biology that seeks to describe the 3-dimensional structures of proteins in correlation with their functions not only serves as the basis for life science research, but also plays a vital role in industrial applications as exemplified in drug developments. Several structural biology projects such as Protein Structure Initiative (http://www.sbkb.org/) and Structural Genomics Consortium (http://www.thesgc. org/about/) are pursuing structures of proteins on a genome wide scale in USA and Europe. In Japan, ‘‘National Project on Protein Structural and Functional Analyses’’ (2002–2006, commonly called ‘‘Protein 3000 Project’’) funded by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan contributed to achieve advances in structural biology and to establish the three dedicated centers for structural biology at SPring-8 (http://www.spring8.or.jp/en/), Photon Factory (http://pf www.kek.jp/index.html), and RIKEN (RIKEN NMR Facility(http://www.ynmr.riken.jp/en/home.html)).

Funding Information:
Protein 3000 Structure Gallery (http://mdbpr4.genes.nig. ac.jp/p3k/index.html.en) is a comprehensive collection of structural data produced from ‘‘Protein 3000 Project’’ (2002–2006) (the preceding project of TPRP) funded by MEXT. The Information Platform team of TPRP produces and maintains the site since one of its missions is to disseminate information on TPRP and its related activities.

Keywords

National project
Protein 3000 Project
Research dissemination
Structural biology
Targeted Proteins Research Program

ASJC Scopus subject areas

Structural Biology
Biochemistry
Genetics

Access to Document

10.1007/s10969-012-9139-1

Cite this

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title = "TP atlas: Integration and dissemination of advances in Targeted Proteins Research Program (TPRP)-structural biology project phase II in Japan",

abstract = "The Targeted Proteins Research Program (TPRP) promoted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan is the phase II of structural biology project (2007-2011) following the Protein 3000 Project (2002-2006) in Japan. While the phase I Protein 3000 Project put partial emphasis on the construction and maintenance of pipelines for structural analyses, the TPRP is dedicated to revealing the structures and functions of the targeted proteins that have great importance in both basic research and industrial applications. To pursue this objective, 35 Targeted Proteins (TP) Projects selected in the three areas of fundamental biology, medicine and pharmacology, and food and environment are tightly collaborated with 10 Advanced Technology (AT) Projects in the four fields of protein production, structural analyses, chemical library and screening, and information platform. Here, the outlines and achievements of the 35 TP Projects are summarized in the system named TP Atlas. Progress in the diversified areas is described in the modules of Graphical Summary, General Summary, Tabular Summary, and Structure Gallery of the TP Atlas in the standard and unified format. Advances in TP Projects owing to novel technologies stemmed from AT Projects and collaborative research among TP Projects are illustrated as a hallmark of the Program. The TP Atlas can be accessed at http://net.genes.nig.ac.jp/tpatlas/index-e.html .",

keywords = "National project, Protein 3000 Project, Research dissemination, Structural biology, Targeted Proteins Research Program",

author = "Takao Iwayanagi and Sei Miyamoto and Takeshi Konno and Hisashi Mizutani and Tomohiro Hirai and Yasumasa Shigemoto and Takashi Gojobori and Hideaki Sugawara",

note = "Funding Information: Structural biology that seeks to describe the 3-dimensional structures of proteins in correlation with their functions not only serves as the basis for life science research, but also plays a vital role in industrial applications as exemplified in drug developments. Several structural biology projects such as Protein Structure Initiative (http://www.sbkb.org/) and Structural Genomics Consortium (http://www.thesgc. org/about/) are pursuing structures of proteins on a genome wide scale in USA and Europe. In Japan, {\textquoteleft}{\textquoteleft}National Project on Protein Structural and Functional Analyses{\textquoteright}{\textquoteright} (2002–2006, commonly called {\textquoteleft}{\textquoteleft}Protein 3000 Project{\textquoteright}{\textquoteright}) funded by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan contributed to achieve advances in structural biology and to establish the three dedicated centers for structural biology at SPring-8 (http://www.spring8.or.jp/en/), Photon Factory (http://pf www.kek.jp/index.html), and RIKEN (RIKEN NMR Facility(http://www.ynmr.riken.jp/en/home.html)). Funding Information: Protein 3000 Structure Gallery (http://mdbpr4.genes.nig. ac.jp/p3k/index.html.en) is a comprehensive collection of structural data produced from {\textquoteleft}{\textquoteleft}Protein 3000 Project{\textquoteright}{\textquoteright} (2002–2006) (the preceding project of TPRP) funded by MEXT. The Information Platform team of TPRP produces and maintains the site since one of its missions is to disseminate information on TPRP and its related activities.",

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doi = "10.1007/s10969-012-9139-1",

language = "English (US)",

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journal = "Journal of Structural and Functional Genomics",

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AU - Mizutani, Hisashi

AU - Hirai, Tomohiro

AU - Shigemoto, Yasumasa

AU - Gojobori, Takashi

AU - Sugawara, Hideaki

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TP atlas: Integration and dissemination of advances in Targeted Proteins Research Program (TPRP)-structural biology project phase II in Japan

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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