Tin-free visible light photoredox catalysed cyclisation of enamides as a mild procedure for the synthesis of γ-lactams

Eleonora Fava; Masaki Nakajima; Martin B. Tabak; Magnus Rueping

doi:10.1039/C6GC01099G

Tin-free visible light photoredox catalysed cyclisation of enamides as a mild procedure for the synthesis of γ-lactams

Eleonora Fava, Masaki Nakajima, Martin B. Tabak, Magnus Rueping

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The first visible light mediated tin-free cyclisation of α-chloroenamides leading to the synthesis of substituted γ-lactams with excellent stereoselectivity is reported. The protocol employs the single-electron reduction of activated C–Cl bonds, which are typically inert towards reduction.

Original language	English (US)
Pages (from-to)	4531-4535
Number of pages	5
Journal	Green Chem.
Volume	18
Issue number	16
DOIs	https://doi.org/10.1039/C6GC01099G
State	Published - 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The research leading to these results has received funding
from the European Research Council under the European
Union’s Seventh Framework Programme (FP/2007-2013)/ERC
Grant Agreement No. 617044 (SunCatChem). Financial support
by KAUST is gratefully acknowledged.

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10.1039/C6GC01099G

https://repository.kaust.edu.sa/bitstream/10754/617240/1/c6gc01099g.pdf

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title = "Tin-free visible light photoredox catalysed cyclisation of enamides as a mild procedure for the synthesis of γ-lactams",

abstract = "The first visible light mediated tin-free cyclisation of α-chloroenamides leading to the synthesis of substituted γ-lactams with excellent stereoselectivity is reported. The protocol employs the single-electron reduction of activated C–Cl bonds, which are typically inert towards reduction.",

author = "Eleonora Fava and Masaki Nakajima and Tabak, {Martin B.} and Magnus Rueping",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The research leading to these results has received funding from the European Research Council under the European Union{\textquoteright}s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement No. 617044 (SunCatChem). Financial support by KAUST is gratefully acknowledged.",

year = "2016",

doi = "10.1039/C6GC01099G",

language = "English (US)",

volume = "18",

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journal = "Green Chem.",

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publisher = "Royal Society of Chemistry",

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T1 - Tin-free visible light photoredox catalysed cyclisation of enamides as a mild procedure for the synthesis of γ-lactams

AU - Fava, Eleonora

AU - Nakajima, Masaki

AU - Tabak, Martin B.

AU - Rueping, Magnus

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement No. 617044 (SunCatChem). Financial support by KAUST is gratefully acknowledged.

PY - 2016

Y1 - 2016

N2 - The first visible light mediated tin-free cyclisation of α-chloroenamides leading to the synthesis of substituted γ-lactams with excellent stereoselectivity is reported. The protocol employs the single-electron reduction of activated C–Cl bonds, which are typically inert towards reduction.

AB - The first visible light mediated tin-free cyclisation of α-chloroenamides leading to the synthesis of substituted γ-lactams with excellent stereoselectivity is reported. The protocol employs the single-electron reduction of activated C–Cl bonds, which are typically inert towards reduction.

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UR - http://www.scopus.com/inward/record.url?scp=84981510257&partnerID=8YFLogxK

U2 - 10.1039/C6GC01099G

DO - 10.1039/C6GC01099G

M3 - Article

SN - 1463-9262

VL - 18

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JO - Green Chem.

JF - Green Chem.

IS - 16

ER -

Tin-free visible light photoredox catalysed cyclisation of enamides as a mild procedure for the synthesis of γ-lactams

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