Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles manipulated and controlled by optical tweezers

Valeria Garbin; Dan Cojoc; Enrico Ferrari; Enzo Di Fabrizio; Marlies Overvelde; Michel Versluis; Sander Van Der Meer; Nico De Jong; Detlef Lohse

doi:10.1117/12.680576

Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles manipulated and controlled by optical tweezers

Valeria Garbin^*, Dan Cojoc, Enrico Ferrari, Enzo Di Fabrizio, Marlies Overvelde, Michel Versluis, Sander Van Der Meer, Nico De Jong, Detlef Lohse

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

Optical tweezers enable non-destructive, contact-free manipulation of ultrasound contrast agent (UCA) microbubbles, which are used in medical imaging for enhancing the echogenicity of the blood pool and to quantify organ perfusion. The understanding of the fundamental dynamics of ultrasound-driven contrast agent microbubbles is a first step for exploiting their acoustical properties and to develop new diagnostic and therapeutic applications. In this respect, optical tweezers can be used to study UCA microbubbles under controlled and repeatable conditions, by positioning them away from interfaces and from neighboring bubbles. In addition, a high-speed imaging system is required to record the dynamics of UCA microbubbles in ultrasound, as their oscillations occur on the nanoseconds timescale. In this work, we demonstrate the use of an optical tweezers system combined with a high-speed camera capable of 128-frame recordings at up to 25 million frames per second (Mfps), for the study of individual UCA microbubble dynamics as a function of the distance from solid interfaces.

Original language	English (US)
Title of host publication	Optical Trapping and Optical Micromanipulation III
DOIs	https://doi.org/10.1117/12.680576
State	Published - 2006
Externally published	Yes
Event	Optical Trapping and Optical Micromanipulation III - San Diego, CA, United States Duration: Aug 13 2006 → Aug 17 2006

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	6326
ISSN (Print)	0277-786X

Other

Other	Optical Trapping and Optical Micromanipulation III
Country/Territory	United States
City	San Diego, CA
Period	08/13/06 → 08/17/06

Keywords

Diffractive optical elements
High speed imaging
Laguerre-Gaussian beam
Low-index particle
Microbubble
Optical tweezers
Optical vortex
Ultrasound contras agent

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

10.1117/12.680576

Cite this

Garbin, V., Cojoc, D., Ferrari, E., Di Fabrizio, E., Overvelde, M., Versluis, M., Van Der Meer, S., De Jong, N., & Lohse, D. (2006). Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles manipulated and controlled by optical tweezers. In Optical Trapping and Optical Micromanipulation III Article 63261V (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6326). https://doi.org/10.1117/12.680576

@inproceedings{e7e67081b06c4a1aaf0d01029e1391e8,

title = "Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles manipulated and controlled by optical tweezers",

abstract = "Optical tweezers enable non-destructive, contact-free manipulation of ultrasound contrast agent (UCA) microbubbles, which are used in medical imaging for enhancing the echogenicity of the blood pool and to quantify organ perfusion. The understanding of the fundamental dynamics of ultrasound-driven contrast agent microbubbles is a first step for exploiting their acoustical properties and to develop new diagnostic and therapeutic applications. In this respect, optical tweezers can be used to study UCA microbubbles under controlled and repeatable conditions, by positioning them away from interfaces and from neighboring bubbles. In addition, a high-speed imaging system is required to record the dynamics of UCA microbubbles in ultrasound, as their oscillations occur on the nanoseconds timescale. In this work, we demonstrate the use of an optical tweezers system combined with a high-speed camera capable of 128-frame recordings at up to 25 million frames per second (Mfps), for the study of individual UCA microbubble dynamics as a function of the distance from solid interfaces.",

keywords = "Diffractive optical elements, High speed imaging, Laguerre-Gaussian beam, Low-index particle, Microbubble, Optical tweezers, Optical vortex, Ultrasound contras agent",

author = "Valeria Garbin and Dan Cojoc and Enrico Ferrari and {Di Fabrizio}, Enzo and Marlies Overvelde and Michel Versluis and {Van Der Meer}, Sander and {De Jong}, Nico and Detlef Lohse",

year = "2006",

doi = "10.1117/12.680576",

language = "English (US)",

isbn = "0819464058",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

booktitle = "Optical Trapping and Optical Micromanipulation III",

note = "Optical Trapping and Optical Micromanipulation III ; Conference date: 13-08-2006 Through 17-08-2006",

}

Garbin, V, Cojoc, D, Ferrari, E, Di Fabrizio, E, Overvelde, M, Versluis, M, Van Der Meer, S, De Jong, N & Lohse, D 2006, Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles manipulated and controlled by optical tweezers. in Optical Trapping and Optical Micromanipulation III., 63261V, Proceedings of SPIE - The International Society for Optical Engineering, vol. 6326, Optical Trapping and Optical Micromanipulation III, San Diego, CA, United States, 08/13/06. https://doi.org/10.1117/12.680576

Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles manipulated and controlled by optical tweezers. / Garbin, Valeria; Cojoc, Dan; Ferrari, Enrico et al.
Optical Trapping and Optical Micromanipulation III. 2006. 63261V (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6326).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Garbin, Valeria

AU - Cojoc, Dan

AU - Ferrari, Enrico

AU - Di Fabrizio, Enzo

AU - Overvelde, Marlies

AU - Versluis, Michel

AU - Van Der Meer, Sander

AU - De Jong, Nico

AU - Lohse, Detlef

PY - 2006

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N2 - Optical tweezers enable non-destructive, contact-free manipulation of ultrasound contrast agent (UCA) microbubbles, which are used in medical imaging for enhancing the echogenicity of the blood pool and to quantify organ perfusion. The understanding of the fundamental dynamics of ultrasound-driven contrast agent microbubbles is a first step for exploiting their acoustical properties and to develop new diagnostic and therapeutic applications. In this respect, optical tweezers can be used to study UCA microbubbles under controlled and repeatable conditions, by positioning them away from interfaces and from neighboring bubbles. In addition, a high-speed imaging system is required to record the dynamics of UCA microbubbles in ultrasound, as their oscillations occur on the nanoseconds timescale. In this work, we demonstrate the use of an optical tweezers system combined with a high-speed camera capable of 128-frame recordings at up to 25 million frames per second (Mfps), for the study of individual UCA microbubble dynamics as a function of the distance from solid interfaces.

AB - Optical tweezers enable non-destructive, contact-free manipulation of ultrasound contrast agent (UCA) microbubbles, which are used in medical imaging for enhancing the echogenicity of the blood pool and to quantify organ perfusion. The understanding of the fundamental dynamics of ultrasound-driven contrast agent microbubbles is a first step for exploiting their acoustical properties and to develop new diagnostic and therapeutic applications. In this respect, optical tweezers can be used to study UCA microbubbles under controlled and repeatable conditions, by positioning them away from interfaces and from neighboring bubbles. In addition, a high-speed imaging system is required to record the dynamics of UCA microbubbles in ultrasound, as their oscillations occur on the nanoseconds timescale. In this work, we demonstrate the use of an optical tweezers system combined with a high-speed camera capable of 128-frame recordings at up to 25 million frames per second (Mfps), for the study of individual UCA microbubble dynamics as a function of the distance from solid interfaces.

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KW - High speed imaging

KW - Laguerre-Gaussian beam

KW - Low-index particle

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KW - Optical vortex

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AN - SCOPUS:33751429398

SN - 0819464058

SN - 9780819464057

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Optical Trapping and Optical Micromanipulation III

T2 - Optical Trapping and Optical Micromanipulation III

Y2 - 13 August 2006 through 17 August 2006

ER -

Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles manipulated and controlled by optical tweezers

Abstract

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Keywords

ASJC Scopus subject areas

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