Three-dimensionally two-photon lithography realized vascular grafts.

Tania Limongi, Laura Brigo, Luca Tirinato, Francesca Pagliari, Alessandro Gandin, Paolo Contessotto, Andrea Giugni, Giovanna Brusatin

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Generation of artifical vascular grafts (TEVG) as blood vessel substitutes is a primary challenge in biomaterial and tissue engineering research. Ideally, these grafts should be able to recapitulate physiological and mechanical properties of natural vessels and guide the assembly of an endothelial cell lining to ensure hemo-compatibility. In this paper, we advance on this challenging task by designing and fabricating 3D vessel analogues by two-photon laser lithography using a synthetic photoresist. These scaffolds guarantee human endothelial cell adhesion and proliferation, and proper elastic behaviour to withstand the pressure exerted by blood flow.
Original languageEnglish (US)
JournalBiomedical materials (Bristol, England)
StatePublished - Nov 13 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-11-16
Acknowledged KAUST grant number(s): OCRF-2016-CRG5
Acknowledgements: G. B. acknowledges the University of Padova for financial support of through "Finanziamento per le attrezzature scientifiche finalizzate alla ricerca - Bando 2013" and SID project “3D Engineered Biopolymers Micro Fabrication by Two-Photon Laser Additive Manufacturing”. A. G. acknowledges financial support from the KAUST funding through CRG5 project OSR award #: OCRF-2016-CRG5.


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