Abstract
Asymmetric hydrogenations are of great importance in the synthesis of optically active amines. This account highlights the development of the first metal-free transfer hydrogenation that is both highly enantioselective and inspired by natures dehydrogen?ase. Further focus is given to the extension of this bioinspired process to provide a variety of valuable, biologically active products and natural products under mild reaction conditions.
Original language | English (US) |
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Pages (from-to) | 852-865 |
Number of pages | 14 |
Journal | Synlett |
Issue number | 6 |
DOIs | |
State | Published - 2010 |
Externally published | Yes |
Keywords
- Asymmetric reduction
- Binol phosphate
- Br?nsted acid
- Hantzsch ester
- Organocatalysis
- Transfer hydrogenation
ASJC Scopus subject areas
- Organic Chemistry