Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004

Zhuang Han, Yong-Xin Li, Ling-Li Liu, Liang Lu, Xianrong Guo, Xixiang Zhang, Xiao-Yong Zhang, Shu-Hua Qi, Ying Xu, Pei-Yuan Qian

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9 Scopus citations


Eleven new depsides-thielavins W-Z (1-4) and thielavins Z₁-Z₇ (5-11)-and also four known thielavins-A, H, J, and K (12-15)-were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1-3 and 6-13 were active, with EC50 values ranging from 2.95 ± 0.59 to 69.19 ± 9.51 μM, respectively. The inhibitive effect of compounds 1-3 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids.
Original languageEnglish (US)
Pages (from-to)128
JournalMarine Drugs
Issue number5
StatePublished - Apr 29 2017

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We are grateful for the financial support from the China Ocean Mineral Resources Research and Development Association (DY135), Youth Innovation Promotion Association CAS (QC2015388), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB06010204), Hainan Special Project for Ocean Exploration (XH201410), the Natural Science Foundation of Hainan Province (414186), and Institute of Deep-Sea Science and Engineering (SIDSSE-QN-201303).


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