Vanadium is a hard, silver-grey transition metal found in at least 60 minerals and fossil fuel deposits. Its oxide and other vanadium salts are toxic to humans, but the toxic effects depend on the vanadium form, dose, exposure duration, and route of intoxication. Vanadium is used by some life forms as an active center in enzymes, such as the vanadium bromoperoxidase of ocean algae and nitrogenases of bacteria. The structure and biochemistry of vanadate resemble those of phosphate, hence vanadate can be regarded as a phosphate competitor in a variety of biochemical enzymes such as kinases and phosphatases. In this review, we describe the biochemical pathways regulated by vanadium compounds and their potential therapeutic benefits for a range of disorders including type 2 diabetes, cancer, cardiovascular disease, and microbial pathology.
|Original language||English (US)|
|State||Published - Dec 6 2022|
Bibliographical noteKAUST Repository Item: Exported on 2022-12-08
Acknowledged KAUST grant number(s): BAS/1/1085-01-01
Acknowledgements: This research received no external funding. We would like to thank Peter Karagiannis, King Abdullah University of Science and Technology (KAUST), Core Labs, for his valuable comments and edits. M.J. would like to thank KAUST for financial support (baseline no. BAS/1/1085-01-01).