The synaptic NMDA component desynchronizes neural bursters

Jesper Tegnér; Jeanette Hellgren-Kotaleski

doi:10.1016/S0925-2312(99)00034-X

The synaptic NMDA component desynchronizes neural bursters

Jesper Tegnér^*, Jeanette Hellgren-Kotaleski

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The influence of excitatory and inhibitory coupling on synchronization depends on the temporal dynamics of the synapse. Slow excitation is desynchronizing whereas fast excitation tends to synchronize neuronal firing. Excitation via glutamatergic synapses, however, activates both ionotropic AMPA/kainate and NMDA receptors. Here we analyze the role of the synaptic NMDA component. We show that slowly bursting neurons desynchronize when connected by symmetrical NMDA synapses whereas they tend to synchronize when coupled with symmetrical AMPA/kainate synapses. This suggests that the effect on synchronization of an excitatory synapse also depends on the relative proportion of NMDA and AMPA/kainate synapses.

Original language	English (US)
Pages (from-to)	557-563
Number of pages	7
Journal	Neurocomputing
Volume	26-27
DOIs	https://doi.org/10.1016/S0925-2312(99)00034-X
State	Published - Jun 1999
Externally published	Yes

Bibliographical note

Funding Information:
We thank Eugene M. Izhikewich for useful discussions and Bard G. Ermentrout for making XPP available. This work was supported by the Royal Swedish Academy of Sciences and funds from Lennanders Stiftelse.

Keywords

Bursters
Calcium
Slow variable
Synchronization

ASJC Scopus subject areas

Computer Science Applications
Cognitive Neuroscience
Artificial Intelligence

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10.1016/S0925-2312(99)00034-X

Cite this

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title = "The synaptic NMDA component desynchronizes neural bursters",

abstract = "The influence of excitatory and inhibitory coupling on synchronization depends on the temporal dynamics of the synapse. Slow excitation is desynchronizing whereas fast excitation tends to synchronize neuronal firing. Excitation via glutamatergic synapses, however, activates both ionotropic AMPA/kainate and NMDA receptors. Here we analyze the role of the synaptic NMDA component. We show that slowly bursting neurons desynchronize when connected by symmetrical NMDA synapses whereas they tend to synchronize when coupled with symmetrical AMPA/kainate synapses. This suggests that the effect on synchronization of an excitatory synapse also depends on the relative proportion of NMDA and AMPA/kainate synapses.",

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AU - Hellgren-Kotaleski, Jeanette

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PY - 1999/6

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N2 - The influence of excitatory and inhibitory coupling on synchronization depends on the temporal dynamics of the synapse. Slow excitation is desynchronizing whereas fast excitation tends to synchronize neuronal firing. Excitation via glutamatergic synapses, however, activates both ionotropic AMPA/kainate and NMDA receptors. Here we analyze the role of the synaptic NMDA component. We show that slowly bursting neurons desynchronize when connected by symmetrical NMDA synapses whereas they tend to synchronize when coupled with symmetrical AMPA/kainate synapses. This suggests that the effect on synchronization of an excitatory synapse also depends on the relative proportion of NMDA and AMPA/kainate synapses.

AB - The influence of excitatory and inhibitory coupling on synchronization depends on the temporal dynamics of the synapse. Slow excitation is desynchronizing whereas fast excitation tends to synchronize neuronal firing. Excitation via glutamatergic synapses, however, activates both ionotropic AMPA/kainate and NMDA receptors. Here we analyze the role of the synaptic NMDA component. We show that slowly bursting neurons desynchronize when connected by symmetrical NMDA synapses whereas they tend to synchronize when coupled with symmetrical AMPA/kainate synapses. This suggests that the effect on synchronization of an excitatory synapse also depends on the relative proportion of NMDA and AMPA/kainate synapses.

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KW - Calcium

KW - Slow variable

KW - Synchronization

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ER -

The synaptic NMDA component desynchronizes neural bursters

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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