TY - JOUR
T1 - The senescence-associated secretory phenotype as a driver of tumor growth: does G3BP1 hold the key?
AU - Omer, Amr
AU - Di Marco, Sergio
AU - Gallouzi, Imed Eddine
N1 - Generated from Scopus record by KAUST IRTS on 2022-09-13
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Cellular senescence is a double-edged sword that, depending on the context, acts as either a potent tumor protective mechanism or an age-related driver of diseases such as cancer. Our recent findings show that the rasGAP SH3-binding protein 1 (G3BP1) activates the senescent-associated secretory phenotype (SASP) that, in turn, mediates cancer growth/progression.
AB - Cellular senescence is a double-edged sword that, depending on the context, acts as either a potent tumor protective mechanism or an age-related driver of diseases such as cancer. Our recent findings show that the rasGAP SH3-binding protein 1 (G3BP1) activates the senescent-associated secretory phenotype (SASP) that, in turn, mediates cancer growth/progression.
UR - https://www.tandfonline.com/doi/full/10.1080/23723556.2020.1850161
UR - http://www.scopus.com/inward/record.url?scp=85099390538&partnerID=8YFLogxK
U2 - 10.1080/23723556.2020.1850161
DO - 10.1080/23723556.2020.1850161
M3 - Article
C2 - 33553605
SN - 2372-3556
VL - 8
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
IS - 1
ER -
