Background: The practice and research of medicine generates considerable quantities of data and model resources (DMRs). Although in principle biomedical resources are re-usable, in practice few can currently be shared. In particular, the clinical communities in physiology and pharmacology research, as well as medical education, (i.e. PPME communities) are facing considerable operational and technical obstacles in sharing data and models. Findings. We outline the efforts of the PPME communities to achieve automated semantic interoperability for clinical resource documentation in collaboration with the RICORDO project. Current community practices in resource documentation and knowledge management are overviewed. Furthermore, requirements and improvements sought by the PPME communities to current documentation practices are discussed. The RICORDO plan and effort in creating a representational framework and associated open software toolkit for the automated management of PPME metadata resources is also described. Conclusions: RICORDO is providing the PPME community with tools to effect, share and reason over clinical resource annotations. This work is contributing to the semantic interoperability of DMRs through ontology-based annotation by (i) supporting more effective navigation and re-use of clinical DMRs, as well as (ii) sustaining interoperability operations based on the criterion of biological similarity. Operations facilitated by RICORDO will range from automated dataset matching to model merging and managing complex simulation workflows. In effect, RICORDO is contributing to community standards for resource sharing and interoperability.
Bibliographical noteFunding Information:
The contribution and feedback to the manuscript is gratefully acknowledged from: 1) Kerstin Forsberg (Astrazeneca) 2) Bo Andresson (Astrazeneca) 3) Peter Hunter (Auckland, New Zealand). This work is supported by the following grant funding: 1) the European Commission, grant agreement number 248502 (RICORDO) and 223920 (VPH NoE) within the 7th Framework Programme.; 2) Biotechnology and Biological Sciences Research Council (BBSRC) grant BBG0043581 3) Innovative Medicines Initiative (IMI) grant 115156-2 (DDMoRe).
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)