The preparation of 1,2,3-trisubstituted guanidines

Alan R. Katritzky*, Niveen M. Khashab, Sergey Bobrov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


An operationally straightforward and efficient benzotriazole-based method for the guanylation of diverse amines by use of the new reagent classes (bis-benzotriazol-1-yl-methylene)amines 13a-13f and benzotriazole-1- carboxamidines 17a-17i is described. The preparation is described for a variety of both acyclic and cyclic 1,2,3-trisubstituted guanidines in high yields.

Original languageEnglish (US)
Pages (from-to)1664-1675
Number of pages12
JournalHelvetica Chimica Acta
Issue number7
StatePublished - 2005
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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