The mechanism of visible light-induced C–C cross-coupling by Csp3–H bond activation

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2 Scopus citations


Csp3–C cross-coupling by activating Csp3–H bonds is a dream reaction for the chemical community, and visible light-induced transition metal-catalysis under mild reaction conditions is considered a powerful tool to achieve it. Advancement of this research area is still in its infancy because of the chemical and technical complexity of this catalysis. Mechanistic studies illuminating the operative reaction pathways can rationalize the increasing amount of experimental catalysis data and provide the knowledge allowing faster and rational advances in the field. This goal requires complementary experimental and theoretical mechanistic studies, as each of them is unfit to clarify the operative mechanisms alone. In this tutorial review we summarize representative experimental and computational mechanistic studies, highlighting weaknesses, strengths, and synergies between the two approaches.
Original languageEnglish (US)
JournalChemical Society Reviews
StatePublished - Jul 19 2023

Bibliographical note

KAUST Repository Item: Exported on 2023-07-21
Acknowledgements: This project was supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia.

ASJC Scopus subject areas

  • General Chemistry


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