The long road to engineering durable disease resistance in wheat

Brande BH Wulff, Simon G. Krattinger

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


A rich past of generating and configuring genetic structures in wheat (Triticum aestivum) combined with advances in DNA sequencing, bioinformatics and genome engineering has transformed the field of wheat functional genomics. Cloning a gene from the large and complex wheat genome is no longer unattainable; in the past 5 years alone, the molecular identity of 33 wheat disease resistance genes has been elucidated. The next 15 years will see the cloning of most of the 460 known wheat resistance genes and their corresponding effectors. Coupled with mechanistic insights into how resistance genes, effectors and pathogenicity targets interact and are affected by different genetic backgrounds, this will drive systems biology and synthetic engineering studies towards the alluring goal of generating durable disease resistance in wheat.
Original languageEnglish (US)
Pages (from-to)270-275
Number of pages6
JournalCurrent Opinion in Biotechnology
StatePublished - Sep 24 2021

Bibliographical note

KAUST Repository Item: Exported on 2021-09-27
Acknowledgements: We would like to thank Robyn Palescandolo and Tobin Florio for help with figure preparation. This work was funded by the King Abdullah University of Science and Technology.

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering
  • Biotechnology


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