The intracellular region of Notch ligands: Does the tail make the difference?

Alessandro Pintar, Alfredo De Biasio, Matija Popovic, Neli Ivanova, Sándor Pongor

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role of Notch ligands intracellular region in bidirectional signaling and possibly in signal modulation in mammals. © 2007 Pintar et al; licensee BioMed Central Ltd.
Original languageEnglish (US)
JournalBiology Direct
Volume2
DOIs
StatePublished - Jul 10 2007
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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