The global distribution and environmental drivers of the soil antibiotic resistome

Manuel Delgado-Baquerizo; Hang Wei Hu; Fernando T. Maestre; Carlos A. Guerra; Nico Eisenhauer; David J. Eldridge; Yong Guan Zhu; Qing Lin Chen; Pankaj Trivedi; Shuai Du; Thulani P. Makhalanyane; Jay Prakash Verma; Beatriz Gozalo; Victoria Ochoa; Sergio Asensio; Ling Wang; Eli Zaady; Javier G. Illán; Christina Siebe; Tine Grebenc; Xiaobing Zhou; Yu Rong Liu; Adebola R. Bamigboye; José L. Blanco-Pastor; Jorge Duran; Alexandra Rodríguez; Steven Mamet; Fernando Alfaro; Sebastian Abades; Alberto L. Teixido; Gabriel F. Peñaloza-Bojacá; Marco A. Molina-Montenegro; Cristian Torres-Díaz; Cecilia Perez; Antonio Gallardo; Laura García-Velázquez; Patrick E. Hayes; Sigrid Neuhauser; Ji Zheng He

doi:10.1186/s40168-022-01405-w

The global distribution and environmental drivers of the soil antibiotic resistome

Manuel Delgado-Baquerizo^*, Hang Wei Hu^*, Fernando T. Maestre, Carlos A. Guerra, Nico Eisenhauer, David J. Eldridge, Yong Guan Zhu, Qing Lin Chen, Pankaj Trivedi, Shuai Du, Thulani P. Makhalanyane, Jay Prakash Verma, Beatriz Gozalo, Victoria Ochoa, Sergio Asensio, Ling Wang, Eli Zaady, Javier G. Illán, Christina Siebe, Tine GrebencXiaobing Zhou, Yu Rong Liu, Adebola R. Bamigboye, José L. Blanco-Pastor, Jorge Duran, Alexandra Rodríguez, Steven Mamet, Fernando Alfaro, Sebastian Abades, Alberto L. Teixido, Gabriel F. Peñaloza-Bojacá, Marco A. Molina-Montenegro, Cristian Torres-Díaz, Cecilia Perez, Antonio Gallardo, Laura García-Velázquez, Patrick E. Hayes, Sigrid Neuhauser, Ji Zheng He^*

^*Corresponding author for this work

Environmental Science and Engineering

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Background: Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth’s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs. Results: We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs. Conclusions: Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome. [MediaObject not available: see fulltext.].

Original language	English (US)
Article number	219
Journal	Microbiome
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s40168-022-01405-w
State	Published - Dec 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).

Keywords

Antibiotic resistance
Global change
Global scale
Human health
Mobile genetic elements

ASJC Scopus subject areas

Microbiology
Microbiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s40168-022-01405-w

Cite this

Delgado-Baquerizo, M., Hu, H. W., Maestre, F. T., Guerra, C. A., Eisenhauer, N., Eldridge, D. J., Zhu, Y. G., Chen, Q. L., Trivedi, P., Du, S., Makhalanyane, T. P., Verma, J. P., Gozalo, B., Ochoa, V., Asensio, S., Wang, L., Zaady, E., Illán, J. G., Siebe, C., ... He, J. Z. (2022). The global distribution and environmental drivers of the soil antibiotic resistome. Microbiome, 10(1), Article 219. https://doi.org/10.1186/s40168-022-01405-w

@article{dfa9bba602784214bb4ea82aa34e77fb,

title = "The global distribution and environmental drivers of the soil antibiotic resistome",

abstract = "Background: Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth{\textquoteright}s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs. Results: We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs. Conclusions: Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome. [MediaObject not available: see fulltext.].",

keywords = "Antibiotic resistance, Global change, Global scale, Human health, Mobile genetic elements",

author = "Manuel Delgado-Baquerizo and Hu, {Hang Wei} and Maestre, {Fernando T.} and Guerra, {Carlos A.} and Nico Eisenhauer and Eldridge, {David J.} and Zhu, {Yong Guan} and Chen, {Qing Lin} and Pankaj Trivedi and Shuai Du and Makhalanyane, {Thulani P.} and Verma, {Jay Prakash} and Beatriz Gozalo and Victoria Ochoa and Sergio Asensio and Ling Wang and Eli Zaady and Ill{\'a}n, {Javier G.} and Christina Siebe and Tine Grebenc and Xiaobing Zhou and Liu, {Yu Rong} and Bamigboye, {Adebola R.} and Blanco-Pastor, {Jos{\'e} L.} and Jorge Duran and Alexandra Rodr{\'i}guez and Steven Mamet and Fernando Alfaro and Sebastian Abades and Teixido, {Alberto L.} and Pe{\~n}aloza-Bojac{\'a}, {Gabriel F.} and Molina-Montenegro, {Marco A.} and Cristian Torres-D{\'i}az and Cecilia Perez and Antonio Gallardo and Laura Garc{\'i}a-Vel{\'a}zquez and Hayes, {Patrick E.} and Sigrid Neuhauser and He, {Ji Zheng}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1186/s40168-022-01405-w",

language = "English (US)",

volume = "10",

journal = "Microbiome",

issn = "2049-2618",

publisher = "BioMed Central Ltd.",

number = "1",

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Delgado-Baquerizo, M, Hu, HW, Maestre, FT, Guerra, CA, Eisenhauer, N, Eldridge, DJ, Zhu, YG, Chen, QL, Trivedi, P, Du, S, Makhalanyane, TP, Verma, JP, Gozalo, B, Ochoa, V, Asensio, S, Wang, L, Zaady, E, Illán, JG, Siebe, C, Grebenc, T, Zhou, X, Liu, YR, Bamigboye, AR, Blanco-Pastor, JL, Duran, J, Rodríguez, A, Mamet, S, Alfaro, F, Abades, S, Teixido, AL, Peñaloza-Bojacá, GF, Molina-Montenegro, MA, Torres-Díaz, C, Perez, C, Gallardo, A, García-Velázquez, L, Hayes, PE, Neuhauser, S & He, JZ 2022, 'The global distribution and environmental drivers of the soil antibiotic resistome', Microbiome, vol. 10, no. 1, 219. https://doi.org/10.1186/s40168-022-01405-w

TY - JOUR

T1 - The global distribution and environmental drivers of the soil antibiotic resistome

AU - Delgado-Baquerizo, Manuel

AU - Hu, Hang Wei

AU - Maestre, Fernando T.

AU - Guerra, Carlos A.

AU - Eisenhauer, Nico

AU - Eldridge, David J.

AU - Zhu, Yong Guan

AU - Chen, Qing Lin

AU - Trivedi, Pankaj

AU - Du, Shuai

AU - Makhalanyane, Thulani P.

AU - Verma, Jay Prakash

AU - Gozalo, Beatriz

AU - Ochoa, Victoria

AU - Asensio, Sergio

AU - Wang, Ling

AU - Zaady, Eli

AU - Illán, Javier G.

AU - Siebe, Christina

AU - Grebenc, Tine

AU - Zhou, Xiaobing

AU - Liu, Yu Rong

AU - Bamigboye, Adebola R.

AU - Blanco-Pastor, José L.

AU - Duran, Jorge

AU - Rodríguez, Alexandra

AU - Mamet, Steven

AU - Alfaro, Fernando

AU - Abades, Sebastian

AU - Teixido, Alberto L.

AU - Peñaloza-Bojacá, Gabriel F.

AU - Molina-Montenegro, Marco A.

AU - Torres-Díaz, Cristian

AU - Perez, Cecilia

AU - Gallardo, Antonio

AU - García-Velázquez, Laura

AU - Hayes, Patrick E.

AU - Neuhauser, Sigrid

AU - He, Ji Zheng

PY - 2022/12

Y1 - 2022/12

N2 - Background: Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth’s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs. Results: We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs. Conclusions: Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome. [MediaObject not available: see fulltext.].

AB - Background: Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth’s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs. Results: We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs. Conclusions: Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome. [MediaObject not available: see fulltext.].

KW - Antibiotic resistance

KW - Global change

KW - Global scale

KW - Human health

KW - Mobile genetic elements

UR - http://www.scopus.com/inward/record.url?scp=85143804165&partnerID=8YFLogxK

U2 - 10.1186/s40168-022-01405-w

DO - 10.1186/s40168-022-01405-w

M3 - Article

C2 - 36503688

AN - SCOPUS:85143804165

SN - 2049-2618

VL - 10

JO - Microbiome

JF - Microbiome

IS - 1

M1 - 219

ER -

The global distribution and environmental drivers of the soil antibiotic resistome

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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