Abstract
(Chemical Equation Presented) Simple yet efficient: A series of diverse substituted tetrahydroquinoxalines and dihydroquinoxalinones have been synthesized for the first time in a highly enantioselective fashion (see scheme). Using this metalfree hydrogenation it is possible to isolate these products, which are of high pharmaceutical interest, in good yields and with excellent enantioselectivities in a minimal number of reaction steps.
Original language | English (US) |
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Pages (from-to) | 2688-2691 |
Number of pages | 4 |
Journal | Chemistry - A European Journal |
Volume | 16 |
Issue number | 9 |
DOIs | |
State | Published - Mar 1 2010 |
Keywords
- Brønsted acid
- Hantzsch ester
- Organocatalysis
- Pyrazine
- Pyridine
- Transfer hydrogenation
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry