The emerging link between cancer, metabolism, and circadian rhythms

Selma Masri, Paolo Sassone-Corsi

Research output: Contribution to journalArticlepeer-review

240 Scopus citations

Abstract

The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, results from animal models and molecular studies underscore emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches, and we discuss the possible design of chronopharmacological strategies.
Original languageEnglish (US)
Pages (from-to)1795-1803
Number of pages9
JournalNature Medicine
Volume24
Issue number12
DOIs
StatePublished - Dec 6 2018
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2022-06-07
Acknowledgements: The Masri laboratory is supported by a K22 Transition Career Development Award through the National Cancer Institute (NCI), the Concern Foundation, and the V Foundation for Cancer Research. Work in the Sassone-Corsi laboratory is supported by NIH (National Institutes of Health), INSERM (Institut National de la Sante et la Recherche Medicale, France), and KAUST (King Abdullah University of Science and Technology, Saudi Arabia).
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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