Abstract
Introduction: In this study, the effects of aerobic exercises and encapsulated ginger extract (GE) into chitosan nanoparticles (CNPs) were investigated on atrial natriuretic peptide (ANP) gene expression and cardiac histopathology in rat models of myocardial infarction. Methods: The 25 male rats were divided into five groups: Isop (85 mg/kg), Isop + CNPs, Isop + GE-CNPs, Isop + AE, and Isop + GE-CNPs + AE. The rats performed AE on a rodent treadmill five days per week for six weeks. GE-CNPs were gavaged to rats at a dose of 500 mg/kg for six weeks. After the end of the treatment period, the expression of ANP genes was carried out by Real-Time PCR. Results: Based on our findings, the highest amount of collagen deposition was in the heart tissue of patient groups and the patient group treated with chitosan nanoparticles (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 34-43 |
| Number of pages | 10 |
| Journal | Journal of Knowledge and Health in Basic Medical Sciences |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 10 2023 |
| Externally published | Yes |
Bibliographical note
KAUST Repository Item: Exported on 2023-05-24Acknowledgements: This work was supported by King Abdullah University of Science and Technology (KAUST) and by the Singapore National Research Foundation (NRF-CRP14-2014-03). We gratefully thank the IT Research Computing Team and Supercomputing Laboratory at KAUST for computational and storage resources as well as precious assistance.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.