The BRI1-Associated Kinase 1, BAK1, Has a Brassinolide-Independent Role in Plant Cell-Death Control

Birgit Kemmerling; Anne Schwedt; Patricia Rodriguez; Sara Mazzotta; Markus Frank; Synan Abu Qamar; Tesfaye Mengiste; Shigeyuki Betsuyaku; Jane E. Parker; Carsten Müssig; Bart P.H.J. Thomma; Catherine Albrecht; Sacco C. de Vries; Heribert Hirt; Thorsten Nürnberger

doi:10.1016/j.cub.2007.05.046

The BRI1-Associated Kinase 1, BAK1, Has a Brassinolide-Independent Role in Plant Cell-Death Control

Birgit Kemmerling, Anne Schwedt, Patricia Rodriguez, Sara Mazzotta, Markus Frank, Synan Abu Qamar, Tesfaye Mengiste, Shigeyuki Betsuyaku, Jane E. Parker, Carsten Müssig, Bart P.H.J. Thomma, Catherine Albrecht, Sacco C. de Vries, Heribert Hirt, Thorsten Nürnberger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

317 Scopus citations

Abstract

Programmed cell death (PCD) is a common host response to microbial infection [1-3]. In plants, PCD is associated with immunity to biotrophic pathogens, but it can also promote disease upon infection by necrotrophic pathogens [4]. Therefore, plant cell-suicide programs must be strictly controlled. Here we demonstrate that the Arabidopsis thaliana Brassinosteroid Insensitive 1 (BRI1)-associated receptor Kinase 1 (BAK1), which operates as a coreceptor of BRI1 in brassinolide (BL)-dependent plant development, also regulates the containment of microbial infection-induced cell death. BAK1-deficient plants develop spreading necrosis upon infection. This is accompanied by production of reactive oxygen intermediates and results in enhanced susceptibility to necrotrophic fungal pathogens. The exogenous application of BL rescues growth defects of bak1 mutants but fails to restore immunity to fungal infection. Moreover, BL-insensitive and -deficient mutants do not exhibit spreading necrosis or enhanced susceptibility to fungal infections. Together, these findings suggest that plant steroid-hormone signaling is dispensable for the containment of infection-induced PCD. We propose a novel, BL-independent function of BAK1 in plant cell-death control that is distinct from its BL-dependent role in plant development.

Original language	English (US)
Pages (from-to)	1116-1122
Number of pages	7
Journal	Current Biology
Volume	17
Issue number	13
DOIs	https://doi.org/10.1016/j.cub.2007.05.046
State	Published - Jul 3 2007
Externally published	Yes

Bibliographical note

Funding Information:
We thank K. Schumacher, J. Chory, T. Nakagawa, A. Gust, and F. Tax for materials; V. Lipka and F. Tax for comments; and M. Tör for sharing data. We acknowledge the Salk Institute, Nottingham Arabidopsis Stock Center (NASC), and American Biological Resource Center (ABRC) collections for mutant seeds and the AtGenExpress Initiative for sharing data sets. This work was supported by the Deutsche Forschungsgemeinschaft (Arabidopsis Functional Genomics Network [AFGN], SFB446) (T.N.), Deutscher Akademischer Austauschdienst (P.R.), the Max-Planck-Society DFG SFB 635 (J.E.P.), and The Japan Society for the Promotion of Young Scientists (S.B.).

Keywords

CELLCYCLE

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cub.2007.05.046

Cite this

Kemmerling, B., Schwedt, A., Rodriguez, P., Mazzotta, S., Frank, M., Qamar, S. A., Mengiste, T., Betsuyaku, S., Parker, J. E., Müssig, C., Thomma, B. P. H. J., Albrecht, C., de Vries, S. C., Hirt, H., & Nürnberger, T. (2007). The BRI1-Associated Kinase 1, BAK1, Has a Brassinolide-Independent Role in Plant Cell-Death Control. Current Biology, 17(13), 1116-1122. https://doi.org/10.1016/j.cub.2007.05.046

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title = "The BRI1-Associated Kinase 1, BAK1, Has a Brassinolide-Independent Role in Plant Cell-Death Control",

abstract = "Programmed cell death (PCD) is a common host response to microbial infection [1-3]. In plants, PCD is associated with immunity to biotrophic pathogens, but it can also promote disease upon infection by necrotrophic pathogens [4]. Therefore, plant cell-suicide programs must be strictly controlled. Here we demonstrate that the Arabidopsis thaliana Brassinosteroid Insensitive 1 (BRI1)-associated receptor Kinase 1 (BAK1), which operates as a coreceptor of BRI1 in brassinolide (BL)-dependent plant development, also regulates the containment of microbial infection-induced cell death. BAK1-deficient plants develop spreading necrosis upon infection. This is accompanied by production of reactive oxygen intermediates and results in enhanced susceptibility to necrotrophic fungal pathogens. The exogenous application of BL rescues growth defects of bak1 mutants but fails to restore immunity to fungal infection. Moreover, BL-insensitive and -deficient mutants do not exhibit spreading necrosis or enhanced susceptibility to fungal infections. Together, these findings suggest that plant steroid-hormone signaling is dispensable for the containment of infection-induced PCD. We propose a novel, BL-independent function of BAK1 in plant cell-death control that is distinct from its BL-dependent role in plant development.",

keywords = "CELLCYCLE",

author = "Birgit Kemmerling and Anne Schwedt and Patricia Rodriguez and Sara Mazzotta and Markus Frank and Qamar, {Synan Abu} and Tesfaye Mengiste and Shigeyuki Betsuyaku and Parker, {Jane E.} and Carsten M{\"u}ssig and Thomma, {Bart P.H.J.} and Catherine Albrecht and {de Vries}, {Sacco C.} and Heribert Hirt and Thorsten N{\"u}rnberger",

note = "Funding Information: We thank K. Schumacher, J. Chory, T. Nakagawa, A. Gust, and F. Tax for materials; V. Lipka and F. Tax for comments; and M. T{\"o}r for sharing data. We acknowledge the Salk Institute, Nottingham Arabidopsis Stock Center (NASC), and American Biological Resource Center (ABRC) collections for mutant seeds and the AtGenExpress Initiative for sharing data sets. This work was supported by the Deutsche Forschungsgemeinschaft (Arabidopsis Functional Genomics Network [AFGN], SFB446) (T.N.), Deutscher Akademischer Austauschdienst (P.R.), the Max-Planck-Society DFG SFB 635 (J.E.P.), and The Japan Society for the Promotion of Young Scientists (S.B.). ",

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doi = "10.1016/j.cub.2007.05.046",

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Kemmerling, B, Schwedt, A, Rodriguez, P, Mazzotta, S, Frank, M, Qamar, SA, Mengiste, T, Betsuyaku, S, Parker, JE, Müssig, C, Thomma, BPHJ, Albrecht, C, de Vries, SC, Hirt, H & Nürnberger, T 2007, 'The BRI1-Associated Kinase 1, BAK1, Has a Brassinolide-Independent Role in Plant Cell-Death Control', Current Biology, vol. 17, no. 13, pp. 1116-1122. https://doi.org/10.1016/j.cub.2007.05.046

TY - JOUR

T1 - The BRI1-Associated Kinase 1, BAK1, Has a Brassinolide-Independent Role in Plant Cell-Death Control

AU - Kemmerling, Birgit

AU - Schwedt, Anne

AU - Rodriguez, Patricia

AU - Mazzotta, Sara

AU - Frank, Markus

AU - Qamar, Synan Abu

AU - Mengiste, Tesfaye

AU - Betsuyaku, Shigeyuki

AU - Parker, Jane E.

AU - Müssig, Carsten

AU - Thomma, Bart P.H.J.

AU - Albrecht, Catherine

AU - de Vries, Sacco C.

AU - Hirt, Heribert

AU - Nürnberger, Thorsten

N1 - Funding Information: We thank K. Schumacher, J. Chory, T. Nakagawa, A. Gust, and F. Tax for materials; V. Lipka and F. Tax for comments; and M. Tör for sharing data. We acknowledge the Salk Institute, Nottingham Arabidopsis Stock Center (NASC), and American Biological Resource Center (ABRC) collections for mutant seeds and the AtGenExpress Initiative for sharing data sets. This work was supported by the Deutsche Forschungsgemeinschaft (Arabidopsis Functional Genomics Network [AFGN], SFB446) (T.N.), Deutscher Akademischer Austauschdienst (P.R.), the Max-Planck-Society DFG SFB 635 (J.E.P.), and The Japan Society for the Promotion of Young Scientists (S.B.).

PY - 2007/7/3

Y1 - 2007/7/3

N2 - Programmed cell death (PCD) is a common host response to microbial infection [1-3]. In plants, PCD is associated with immunity to biotrophic pathogens, but it can also promote disease upon infection by necrotrophic pathogens [4]. Therefore, plant cell-suicide programs must be strictly controlled. Here we demonstrate that the Arabidopsis thaliana Brassinosteroid Insensitive 1 (BRI1)-associated receptor Kinase 1 (BAK1), which operates as a coreceptor of BRI1 in brassinolide (BL)-dependent plant development, also regulates the containment of microbial infection-induced cell death. BAK1-deficient plants develop spreading necrosis upon infection. This is accompanied by production of reactive oxygen intermediates and results in enhanced susceptibility to necrotrophic fungal pathogens. The exogenous application of BL rescues growth defects of bak1 mutants but fails to restore immunity to fungal infection. Moreover, BL-insensitive and -deficient mutants do not exhibit spreading necrosis or enhanced susceptibility to fungal infections. Together, these findings suggest that plant steroid-hormone signaling is dispensable for the containment of infection-induced PCD. We propose a novel, BL-independent function of BAK1 in plant cell-death control that is distinct from its BL-dependent role in plant development.

AB - Programmed cell death (PCD) is a common host response to microbial infection [1-3]. In plants, PCD is associated with immunity to biotrophic pathogens, but it can also promote disease upon infection by necrotrophic pathogens [4]. Therefore, plant cell-suicide programs must be strictly controlled. Here we demonstrate that the Arabidopsis thaliana Brassinosteroid Insensitive 1 (BRI1)-associated receptor Kinase 1 (BAK1), which operates as a coreceptor of BRI1 in brassinolide (BL)-dependent plant development, also regulates the containment of microbial infection-induced cell death. BAK1-deficient plants develop spreading necrosis upon infection. This is accompanied by production of reactive oxygen intermediates and results in enhanced susceptibility to necrotrophic fungal pathogens. The exogenous application of BL rescues growth defects of bak1 mutants but fails to restore immunity to fungal infection. Moreover, BL-insensitive and -deficient mutants do not exhibit spreading necrosis or enhanced susceptibility to fungal infections. Together, these findings suggest that plant steroid-hormone signaling is dispensable for the containment of infection-induced PCD. We propose a novel, BL-independent function of BAK1 in plant cell-death control that is distinct from its BL-dependent role in plant development.

KW - CELLCYCLE

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ER -

The BRI1-Associated Kinase 1, BAK1, Has a Brassinolide-Independent Role in Plant Cell-Death Control

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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