The blood proteome of imminent lung cancer diagnosis

Demetrius Albanes, Karine Alcala, Nicolas Alcala, Christopher I. Amos, Alan A. Arslan, Julie K. Bassett, Paul Brennan, Qiuyin Cai, Chu Chen, Xiaoshuang Feng, Neal D. Freedman, Florence Guida, Rayjean J. Hung, Kristian Hveem, Mikael Johansson, Mattias Johansson, Woon Puay Koh, Arnulf Langhammer, Roger L. Milne, David MullerJustina Onwuka, Elin Pettersen Sørgjerd, Hilary A. Robbins, Howard D. Sesso, Gianluca Severi, Xiao Ou Shu, Sabina Sieri, Karl Smith-Byrne, Victoria Stevens, Lesley Tinker, Anne Tjønneland, Kala Visvanathan, Ying Wang, Renwei Wang, Stephanie Weinstein, Jian Min Yuan, Hana Zahed, Xuehong Zhang, Wei Zheng

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Identification of risk biomarkers may enhance early detection of smoking-related lung cancer. We measured between 392 and 1,162 proteins in blood samples drawn at most three years before diagnosis in 731 smoking-matched case-control sets nested within six prospective cohorts from the US, Europe, Singapore, and Australia. We identify 36 proteins with independently reproducible associations with risk of imminent lung cancer diagnosis (all p < 4 × 10−5). These include a few markers (e.g. CA-125/MUC-16 and CEACAM5/CEA) that have previously been reported in studies using pre-diagnostic blood samples for lung cancer. The 36 proteins include several growth factors (e.g. HGF, IGFBP-1, IGFP-2), tumor necrosis factor-receptors (e.g. TNFRSF6B, TNFRSF13B), and chemokines and cytokines (e.g. CXL17, GDF-15, SCF). The odds ratio per standard deviation range from 1.31 for IGFBP-1 (95% CI: 1.17–1.47) to 2.43 for CEACAM5 (95% CI: 2.04–2.89). We map the 36 proteins to the hallmarks of cancer and find that activation of invasion and metastasis, proliferative signaling, tumor-promoting inflammation, and angiogenesis are most frequently implicated.
Original languageEnglish (US)
JournalNature Communications
Issue number1
StatePublished - Dec 1 2023
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-21

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Chemistry
  • General Physics and Astronomy


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