The Ashbya gossypii Genome as a Tool for Mapping the Ancient Saccharomyces cerevisiae Genome

Fred S. Dietrich; Sylvia Voegeli; Sophie Brachat; Anita Lerch; Krista Gates; Sabine Steiner; Christine Mohr; Rainer Pöhlmann; Philippe Luedi; Sangdun Choi; Rod A. Wing; Albert Flavier; Thomas D. Gaffney; Peter Philippsen

doi:10.1126/science.1095781

The Ashbya gossypii Genome as a Tool for Mapping the Ancient Saccharomyces cerevisiae Genome

Fred S. Dietrich, Sylvia Voegeli, Sophie Brachat, Anita Lerch, Krista Gates, Sabine Steiner, Christine Mohr, Rainer Pöhlmann, Philippe Luedi, Sangdun Choi, Rod A. Wing, Albert Flavier, Thomas D. Gaffney, Peter Philippsen

Research output: Contribution to journal › Article › peer-review

524 Scopus citations

Abstract

We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. Analysis of this pattern revealed 300 inversions and translocations that have occurred since divergence of these two species. It also provided compelling evidence that the evolution of S. cerevisiae included a whole genome duplication or fusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies.

Original language	English (US)
Journal	Science
Volume	304
Issue number	5668
DOIs	https://doi.org/10.1126/science.1095781
State	Published - Apr 9 2004
Externally published	Yes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2019-11-20

Access to Document

10.1126/science.1095781

Cite this

@article{1a19212cc5094411a12b7ff76ee54a6e,

title = "The Ashbya gossypii Genome as a Tool for Mapping the Ancient Saccharomyces cerevisiae Genome",

abstract = "We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. Analysis of this pattern revealed 300 inversions and translocations that have occurred since divergence of these two species. It also provided compelling evidence that the evolution of S. cerevisiae included a whole genome duplication or fusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies.",

author = "Dietrich, {Fred S.} and Sylvia Voegeli and Sophie Brachat and Anita Lerch and Krista Gates and Sabine Steiner and Christine Mohr and Rainer P{\"o}hlmann and Philippe Luedi and Sangdun Choi and Wing, {Rod A.} and Albert Flavier and Gaffney, {Thomas D.} and Peter Philippsen",

note = "Generated from Scopus record by KAUST IRTS on 2019-11-20",

year = "2004",

month = apr,

day = "9",

doi = "10.1126/science.1095781",

language = "English (US)",

volume = "304",

journal = "Science",

issn = "0036-8075",

publisher = "AMER ASSOC ADVANCEMENT SCIENCE",

number = "5668",

}

TY - JOUR

T1 - The Ashbya gossypii Genome as a Tool for Mapping the Ancient Saccharomyces cerevisiae Genome

AU - Dietrich, Fred S.

AU - Voegeli, Sylvia

AU - Brachat, Sophie

AU - Lerch, Anita

AU - Gates, Krista

AU - Steiner, Sabine

AU - Mohr, Christine

AU - Pöhlmann, Rainer

AU - Luedi, Philippe

AU - Choi, Sangdun

AU - Wing, Rod A.

AU - Flavier, Albert

AU - Gaffney, Thomas D.

AU - Philippsen, Peter

N1 - Generated from Scopus record by KAUST IRTS on 2019-11-20

PY - 2004/4/9

Y1 - 2004/4/9

N2 - We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. Analysis of this pattern revealed 300 inversions and translocations that have occurred since divergence of these two species. It also provided compelling evidence that the evolution of S. cerevisiae included a whole genome duplication or fusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies.

AB - We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. Analysis of this pattern revealed 300 inversions and translocations that have occurred since divergence of these two species. It also provided compelling evidence that the evolution of S. cerevisiae included a whole genome duplication or fusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies.

UR - http://www.sciencemag.org/cgi/doi/10.1126/science.1095781

UR - http://www.scopus.com/inward/record.url?scp=11144355642&partnerID=8YFLogxK

U2 - 10.1126/science.1095781

DO - 10.1126/science.1095781

M3 - Article

SN - 0036-8075

VL - 304

JO - Science

JF - Science

IS - 5668

ER -

The Ashbya gossypii Genome as a Tool for Mapping the Ancient Saccharomyces cerevisiae Genome

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this