The apocarotenoid metabolite zaxinone regulates growth and strigolactone biosynthesis in rice

Jian You Wang; Imran Haider; Muhammad Jamil; Valentina Fiorilli; Yoshimoto Saito; Jianing Mi; Lina Baz; Boubacar A. Kountche; Kun Peng Jia; Xiujie Guo; Aparna Balakrishna; Valentine O. Ntui; Beate Reinke; Veronica Volpe; Takashi Gojobori; Ikram Blilou; Luisa Lanfranco; Paola Bonfante; Salim Al-Babili

doi:10.1038/s41467-019-08461-1

The apocarotenoid metabolite zaxinone regulates growth and strigolactone biosynthesis in rice

Jian You Wang, Imran Haider, Muhammad Jamil, Valentina Fiorilli, Yoshimoto Saito, Jianing Mi, Lina Baz, Boubacar A. Kountche, Kun Peng Jia, Xiujie Guo, Aparna Balakrishna, Valentine O. Ntui, Beate Reinke, Veronica Volpe, Takashi Gojobori, Ikram Blilou, Luisa Lanfranco, Paola Bonfante, Salim Al-Babili^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

127 Scopus citations

Abstract

Carotenoid cleavage dioxygenases (CCDs) form hormones and signaling molecules. Here we show that a member of an overlooked plant CCD subfamily from rice, that we name Zaxinone Synthase (ZAS), can produce zaxinone, a novel apocarotenoid metabolite in vitro. Loss-of-function mutants (zas) contain less zaxinone, exhibit retarded growth and showed elevated levels of strigolactones (SLs), a hormone that determines plant architecture, mediates mycorrhization and facilitates infestation by root parasitic weeds, such as Striga spp. Application of zaxinone can rescue zas phenotypes, decrease SL content and release and promote root growth in wild-type seedlings. In conclusion, we show that zaxinone is a key regulator of rice development and biotic interactions and has potential for increasing crop growth and combating Striga, a severe threat to global food security.

Original language	English (US)
Article number	810
Journal	Nature Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-08461-1
State	Published - Dec 1 2019

Bibliographical note

Publisher Copyright:
© 2019, The Author(s).

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41467-019-08461-1

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Wang, J. Y., Haider, I., Jamil, M., Fiorilli, V., Saito, Y., Mi, J., Baz, L., Kountche, B. A., Jia, K. P., Guo, X., Balakrishna, A., Ntui, V. O., Reinke, B., Volpe, V., Gojobori, T., Blilou, I., Lanfranco, L., Bonfante, P., & Al-Babili, S. (2019). The apocarotenoid metabolite zaxinone regulates growth and strigolactone biosynthesis in rice. Nature Communications, 10(1), Article 810. https://doi.org/10.1038/s41467-019-08461-1

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title = "The apocarotenoid metabolite zaxinone regulates growth and strigolactone biosynthesis in rice",

abstract = "Carotenoid cleavage dioxygenases (CCDs) form hormones and signaling molecules. Here we show that a member of an overlooked plant CCD subfamily from rice, that we name Zaxinone Synthase (ZAS), can produce zaxinone, a novel apocarotenoid metabolite in vitro. Loss-of-function mutants (zas) contain less zaxinone, exhibit retarded growth and showed elevated levels of strigolactones (SLs), a hormone that determines plant architecture, mediates mycorrhization and facilitates infestation by root parasitic weeds, such as Striga spp. Application of zaxinone can rescue zas phenotypes, decrease SL content and release and promote root growth in wild-type seedlings. In conclusion, we show that zaxinone is a key regulator of rice development and biotic interactions and has potential for increasing crop growth and combating Striga, a severe threat to global food security.",

author = "Wang, {Jian You} and Imran Haider and Muhammad Jamil and Valentina Fiorilli and Yoshimoto Saito and Jianing Mi and Lina Baz and Kountche, {Boubacar A.} and Jia, {Kun Peng} and Xiujie Guo and Aparna Balakrishna and Ntui, {Valentine O.} and Beate Reinke and Veronica Volpe and Takashi Gojobori and Ikram Blilou and Luisa Lanfranco and Paola Bonfante and Salim Al-Babili",

note = "Publisher Copyright: {\textcopyright} 2019, The Author(s).",

year = "2019",

month = dec,

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doi = "10.1038/s41467-019-08461-1",

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Wang, JY, Haider, I, Jamil, M, Fiorilli, V, Saito, Y, Mi, J, Baz, L, Kountche, BA, Jia, KP, Guo, X, Balakrishna, A, Ntui, VO, Reinke, B, Volpe, V, Gojobori, T , Blilou, I, Lanfranco, L, Bonfante, P & Al-Babili, S 2019, 'The apocarotenoid metabolite zaxinone regulates growth and strigolactone biosynthesis in rice', Nature Communications, vol. 10, no. 1, 810. https://doi.org/10.1038/s41467-019-08461-1

TY - JOUR

T1 - The apocarotenoid metabolite zaxinone regulates growth and strigolactone biosynthesis in rice

AU - Wang, Jian You

AU - Haider, Imran

AU - Jamil, Muhammad

AU - Fiorilli, Valentina

AU - Saito, Yoshimoto

AU - Mi, Jianing

AU - Baz, Lina

AU - Kountche, Boubacar A.

AU - Jia, Kun Peng

AU - Guo, Xiujie

AU - Balakrishna, Aparna

AU - Ntui, Valentine O.

AU - Reinke, Beate

AU - Volpe, Veronica

AU - Gojobori, Takashi

AU - Blilou, Ikram

AU - Lanfranco, Luisa

AU - Bonfante, Paola

AU - Al-Babili, Salim

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Carotenoid cleavage dioxygenases (CCDs) form hormones and signaling molecules. Here we show that a member of an overlooked plant CCD subfamily from rice, that we name Zaxinone Synthase (ZAS), can produce zaxinone, a novel apocarotenoid metabolite in vitro. Loss-of-function mutants (zas) contain less zaxinone, exhibit retarded growth and showed elevated levels of strigolactones (SLs), a hormone that determines plant architecture, mediates mycorrhization and facilitates infestation by root parasitic weeds, such as Striga spp. Application of zaxinone can rescue zas phenotypes, decrease SL content and release and promote root growth in wild-type seedlings. In conclusion, we show that zaxinone is a key regulator of rice development and biotic interactions and has potential for increasing crop growth and combating Striga, a severe threat to global food security.

AB - Carotenoid cleavage dioxygenases (CCDs) form hormones and signaling molecules. Here we show that a member of an overlooked plant CCD subfamily from rice, that we name Zaxinone Synthase (ZAS), can produce zaxinone, a novel apocarotenoid metabolite in vitro. Loss-of-function mutants (zas) contain less zaxinone, exhibit retarded growth and showed elevated levels of strigolactones (SLs), a hormone that determines plant architecture, mediates mycorrhization and facilitates infestation by root parasitic weeds, such as Striga spp. Application of zaxinone can rescue zas phenotypes, decrease SL content and release and promote root growth in wild-type seedlings. In conclusion, we show that zaxinone is a key regulator of rice development and biotic interactions and has potential for increasing crop growth and combating Striga, a severe threat to global food security.

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SN - 2041-1723

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JO - Nature Communications

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The apocarotenoid metabolite zaxinone regulates growth and strigolactone biosynthesis in rice

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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