TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

Stephan Meller; Jeremy Di Domizio; Kui S Voo; Heike C Friedrich; Georgios Chamilos; Dipyaman Ganguly; Curdin Conrad; Josh Gregorio; Didier Le Roy; Thierry Roger; John E Ladbury; Bernhard Homey; Stanley Watowich; Robert L Modlin; Dimitrios P Kontoyiannis; Yong-Jun Liu; Stefan T. Arold; Michel Gilliet

doi:10.1038/ni.3211

TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

Stephan Meller, Jeremy Di Domizio, Kui S Voo, Heike C Friedrich, Georgios Chamilos, Dipyaman Ganguly, Curdin Conrad, Josh Gregorio, Didier Le Roy, Thierry Roger, John E Ladbury, Bernhard Homey, Stanley Watowich, Robert L Modlin, Dimitrios P Kontoyiannis, Yong-Jun Liu, Stefan T. Arold, Michel Gilliet

Research output: Contribution to journal › Article › peer-review

189 Scopus citations

Abstract

Interleukin 17-producing helper T cells (TH 17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human TH17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, TH17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of TH17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death. © 2015 Nature America, Inc.

Original language	English (US)
Pages (from-to)	970-979
Number of pages	10
Journal	Nature Immunology
Volume	16
Issue number	9
DOIs	https://doi.org/10.1038/ni.3211
State	Published - Jul 13 2015

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KAUST Repository Item: Exported on 2020-10-01

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https://repository.kaust.edu.sa/bitstream/10754/594165/1/T17%20cell%20promote.pdf

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Meller, S., Di Domizio, J., Voo, K. S., Friedrich, H. C., Chamilos, G., Ganguly, D., Conrad, C., Gregorio, J., Le Roy, D., Roger, T., Ladbury, J. E., Homey, B., Watowich, S., Modlin, R. L., Kontoyiannis, D. P., Liu, Y.-J., Arold, S. T., & Gilliet, M. (2015). TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nature Immunology, 16(9), 970-979. https://doi.org/10.1038/ni.3211

@article{b389cccf18d04cd7b2dc5bd583f91b5a,

title = "TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26",

abstract = "Interleukin 17-producing helper T cells (TH 17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human TH17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, TH17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of TH17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death. {\textcopyright} 2015 Nature America, Inc.",

author = "Stephan Meller and {Di Domizio}, Jeremy and Voo, {Kui S} and Friedrich, {Heike C} and Georgios Chamilos and Dipyaman Ganguly and Curdin Conrad and Josh Gregorio and {Le Roy}, Didier and Thierry Roger and Ladbury, {John E} and Bernhard Homey and Stanley Watowich and Modlin, {Robert L} and Kontoyiannis, {Dimitrios P} and Yong-Jun Liu and Arold, {Stefan T.} and Michel Gilliet",

note = "KAUST Repository Item: Exported on 2020-10-01",

year = "2015",

month = jul,

day = "13",

doi = "10.1038/ni.3211",

language = "English (US)",

volume = "16",

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Meller, S, Di Domizio, J, Voo, KS, Friedrich, HC, Chamilos, G, Ganguly, D, Conrad, C, Gregorio, J, Le Roy, D, Roger, T, Ladbury, JE, Homey, B, Watowich, S, Modlin, RL, Kontoyiannis, DP, Liu, Y-J, Arold, ST & Gilliet, M 2015, 'TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26', Nature Immunology, vol. 16, no. 9, pp. 970-979. https://doi.org/10.1038/ni.3211

TY - JOUR

T1 - TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

AU - Meller, Stephan

AU - Di Domizio, Jeremy

AU - Voo, Kui S

AU - Friedrich, Heike C

AU - Chamilos, Georgios

AU - Ganguly, Dipyaman

AU - Conrad, Curdin

AU - Gregorio, Josh

AU - Le Roy, Didier

AU - Roger, Thierry

AU - Ladbury, John E

AU - Homey, Bernhard

AU - Watowich, Stanley

AU - Modlin, Robert L

AU - Kontoyiannis, Dimitrios P

AU - Liu, Yong-Jun

AU - Arold, Stefan T.

AU - Gilliet, Michel

N1 - KAUST Repository Item: Exported on 2020-10-01

PY - 2015/7/13

Y1 - 2015/7/13

N2 - Interleukin 17-producing helper T cells (TH 17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human TH17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, TH17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of TH17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death. © 2015 Nature America, Inc.

AB - Interleukin 17-producing helper T cells (TH 17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human TH17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, TH17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of TH17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death. © 2015 Nature America, Inc.

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SN - 1529-2908

VL - 16

SP - 970

EP - 979

JO - Nature Immunology

JF - Nature Immunology

IS - 9

ER -

TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

Abstract

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