Tetrapyrrole Synthesis of Photosynthetic Chromerids Is Likely Homologous to the Unusual Pathway of Apicomplexan Parasites

Ludek Koreny; Roman Sobotka; Jan Janouskovec; Patrick J. Keeling; Miroslav Obornik

doi:10.1105/tpc.111.089102

Tetrapyrrole Synthesis of Photosynthetic Chromerids Is Likely Homologous to the Unusual Pathway of Apicomplexan Parasites

Ludek Koreny, Roman Sobotka, Jan Janouskovec, Patrick J. Keeling, Miroslav Obornik

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Abstract Most photosynthetic eukaryotes synthesize both heme and chlorophyll via a common tetrapyrrole biosynthetic pathway starting from glutamate. This pathway was derived mainly from cyanobacterial predecessor of the plastid and differs from the heme synthesis of the plastid-lacking eukaryotes. Here, we show that the coral-associated alveolate Chromera velia, the closest known photosynthetic relative to Apicomplexa, possesses a tetrapyrrole pathway that is homologous to the unusual pathway of apicomplexan parasites. We also demonstrate that, unlike other eukaryotic phototrophs, Chromera synthesizes chlorophyll from glycine and succinyl-CoA rather than glutamate. Our data shed light on the evolution of the heme biosynthesis in parasitic Apicomplexa and photosynthesis-related biochemical processes in their ancestors.

Original language	English (US)
Pages (from-to)	3454-3462
Number of pages	9
Journal	PLANT CELL
Volume	23
Issue number	9
DOIs	https://doi.org/10.1105/tpc.111.089102
State	Published - 2011
Externally published	Yes

Bibliographical note

KAUST Repository Item: Exported on 2021-09-16
Acknowledged KAUST grant number(s): IC/2010/09
Acknowledgements: This work was supported by the Czech Science Foundation (GA206/08/1423), the Grant Agency of the Academy of Sciences of the Czech Republic (IAA601410907), by Award IC/2010/09 made by King Abdullah University of Science and Technology, by the project Algatech (CZ.1.05/2.1.00/03.0110), and by the Grant Agency of University of South Bohemia (GAJU 146/2010/P) to M.O.; by Institutional Research Concept AV0Z50200510 to R.S.; and by the Canadian Institutes for Health Research (MOP42517) to P.J.K. P.J.K. is a Fellow of the Canadian Institute for Advanced Research and a Senior Scholar of the Michael Smith Foundation for Health Research.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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title = "Tetrapyrrole Synthesis of Photosynthetic Chromerids Is Likely Homologous to the Unusual Pathway of Apicomplexan Parasites",

abstract = "Abstract Most photosynthetic eukaryotes synthesize both heme and chlorophyll via a common tetrapyrrole biosynthetic pathway starting from glutamate. This pathway was derived mainly from cyanobacterial predecessor of the plastid and differs from the heme synthesis of the plastid-lacking eukaryotes. Here, we show that the coral-associated alveolate Chromera velia, the closest known photosynthetic relative to Apicomplexa, possesses a tetrapyrrole pathway that is homologous to the unusual pathway of apicomplexan parasites. We also demonstrate that, unlike other eukaryotic phototrophs, Chromera synthesizes chlorophyll from glycine and succinyl-CoA rather than glutamate. Our data shed light on the evolution of the heme biosynthesis in parasitic Apicomplexa and photosynthesis-related biochemical processes in their ancestors.",

author = "Ludek Koreny and Roman Sobotka and Jan Janouskovec and Keeling, {Patrick J.} and Miroslav Obornik",

note = "KAUST Repository Item: Exported on 2021-09-16 Acknowledged KAUST grant number(s): IC/2010/09 Acknowledgements: This work was supported by the Czech Science Foundation (GA206/08/1423), the Grant Agency of the Academy of Sciences of the Czech Republic (IAA601410907), by Award IC/2010/09 made by King Abdullah University of Science and Technology, by the project Algatech (CZ.1.05/2.1.00/03.0110), and by the Grant Agency of University of South Bohemia (GAJU 146/2010/P) to M.O.; by Institutional Research Concept AV0Z50200510 to R.S.; and by the Canadian Institutes for Health Research (MOP42517) to P.J.K. P.J.K. is a Fellow of the Canadian Institute for Advanced Research and a Senior Scholar of the Michael Smith Foundation for Health Research. This publication acknowledges KAUST support, but has no KAUST affiliated authors.",

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AU - Keeling, Patrick J.

AU - Obornik, Miroslav

N1 - KAUST Repository Item: Exported on 2021-09-16 Acknowledged KAUST grant number(s): IC/2010/09 Acknowledgements: This work was supported by the Czech Science Foundation (GA206/08/1423), the Grant Agency of the Academy of Sciences of the Czech Republic (IAA601410907), by Award IC/2010/09 made by King Abdullah University of Science and Technology, by the project Algatech (CZ.1.05/2.1.00/03.0110), and by the Grant Agency of University of South Bohemia (GAJU 146/2010/P) to M.O.; by Institutional Research Concept AV0Z50200510 to R.S.; and by the Canadian Institutes for Health Research (MOP42517) to P.J.K. P.J.K. is a Fellow of the Canadian Institute for Advanced Research and a Senior Scholar of the Michael Smith Foundation for Health Research. This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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N2 - Abstract Most photosynthetic eukaryotes synthesize both heme and chlorophyll via a common tetrapyrrole biosynthetic pathway starting from glutamate. This pathway was derived mainly from cyanobacterial predecessor of the plastid and differs from the heme synthesis of the plastid-lacking eukaryotes. Here, we show that the coral-associated alveolate Chromera velia, the closest known photosynthetic relative to Apicomplexa, possesses a tetrapyrrole pathway that is homologous to the unusual pathway of apicomplexan parasites. We also demonstrate that, unlike other eukaryotic phototrophs, Chromera synthesizes chlorophyll from glycine and succinyl-CoA rather than glutamate. Our data shed light on the evolution of the heme biosynthesis in parasitic Apicomplexa and photosynthesis-related biochemical processes in their ancestors.

AB - Abstract Most photosynthetic eukaryotes synthesize both heme and chlorophyll via a common tetrapyrrole biosynthetic pathway starting from glutamate. This pathway was derived mainly from cyanobacterial predecessor of the plastid and differs from the heme synthesis of the plastid-lacking eukaryotes. Here, we show that the coral-associated alveolate Chromera velia, the closest known photosynthetic relative to Apicomplexa, possesses a tetrapyrrole pathway that is homologous to the unusual pathway of apicomplexan parasites. We also demonstrate that, unlike other eukaryotic phototrophs, Chromera synthesizes chlorophyll from glycine and succinyl-CoA rather than glutamate. Our data shed light on the evolution of the heme biosynthesis in parasitic Apicomplexa and photosynthesis-related biochemical processes in their ancestors.

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Tetrapyrrole Synthesis of Photosynthetic Chromerids Is Likely Homologous to the Unusual Pathway of Apicomplexan Parasites

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