Targeted cancer cell death induced by biofunctionalized magnetic nanowires

Maria F. Contreras; Timothy Ravasi; Jürgen Kosel

doi:10.1109/MECBME.2014.6783203

Targeted cancer cell death induced by biofunctionalized magnetic nanowires

Maria F. Contreras, Timothy Ravasi, Jürgen Kosel

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

Magnetic micro and nanomaterials are increasingly interesting for biomedical applications since they possess many advantageous properties: they can become biocompatible, they can be functionalized to target specific cells and they can be remotely manipulated by magnetic fields. The goal of this study is to use antibody-functionalized nickel nanowires (Ab-NWs) as an alternative method in cancer therapy overcoming the limitations of current treatments that lack specificity and are highly cytotoxic. Ab-NWs have been incubated with cancer cells and a 12% drop on cell viability was observed for a treatment of only 10 minutes and an alternating magnetic field of low intensity and low frequency. It is believed that the Ab-NWs vibrate transmitting a mechanical force to the targeted cells inducing cell death. © 2014 IEEE.

Original language	English (US)
Title of host publication	2nd Middle East Conference on Biomedical Engineering
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Pages	47-50
Number of pages	4
ISBN (Print)	9781479947997
DOIs	https://doi.org/10.1109/MECBME.2014.6783203
State	Published - Feb 2014

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/MECBME.2014.6783203

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title = "Targeted cancer cell death induced by biofunctionalized magnetic nanowires",

abstract = "Magnetic micro and nanomaterials are increasingly interesting for biomedical applications since they possess many advantageous properties: they can become biocompatible, they can be functionalized to target specific cells and they can be remotely manipulated by magnetic fields. The goal of this study is to use antibody-functionalized nickel nanowires (Ab-NWs) as an alternative method in cancer therapy overcoming the limitations of current treatments that lack specificity and are highly cytotoxic. Ab-NWs have been incubated with cancer cells and a 12% drop on cell viability was observed for a treatment of only 10 minutes and an alternating magnetic field of low intensity and low frequency. It is believed that the Ab-NWs vibrate transmitting a mechanical force to the targeted cells inducing cell death. {\textcopyright} 2014 IEEE.",

author = "Contreras, {Maria F.} and Timothy Ravasi and J{\"u}rgen Kosel",

note = "KAUST Repository Item: Exported on 2020-10-01",

year = "2014",

month = feb,

doi = "10.1109/MECBME.2014.6783203",

language = "English (US)",

isbn = "9781479947997",

pages = "47--50",

booktitle = "2nd Middle East Conference on Biomedical Engineering",

publisher = "Institute of Electrical and Electronics Engineers (IEEE)",

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TY - GEN

T1 - Targeted cancer cell death induced by biofunctionalized magnetic nanowires

AU - Contreras, Maria F.

AU - Ravasi, Timothy

AU - Kosel, Jürgen

N1 - KAUST Repository Item: Exported on 2020-10-01

PY - 2014/2

Y1 - 2014/2

N2 - Magnetic micro and nanomaterials are increasingly interesting for biomedical applications since they possess many advantageous properties: they can become biocompatible, they can be functionalized to target specific cells and they can be remotely manipulated by magnetic fields. The goal of this study is to use antibody-functionalized nickel nanowires (Ab-NWs) as an alternative method in cancer therapy overcoming the limitations of current treatments that lack specificity and are highly cytotoxic. Ab-NWs have been incubated with cancer cells and a 12% drop on cell viability was observed for a treatment of only 10 minutes and an alternating magnetic field of low intensity and low frequency. It is believed that the Ab-NWs vibrate transmitting a mechanical force to the targeted cells inducing cell death. © 2014 IEEE.

AB - Magnetic micro and nanomaterials are increasingly interesting for biomedical applications since they possess many advantageous properties: they can become biocompatible, they can be functionalized to target specific cells and they can be remotely manipulated by magnetic fields. The goal of this study is to use antibody-functionalized nickel nanowires (Ab-NWs) as an alternative method in cancer therapy overcoming the limitations of current treatments that lack specificity and are highly cytotoxic. Ab-NWs have been incubated with cancer cells and a 12% drop on cell viability was observed for a treatment of only 10 minutes and an alternating magnetic field of low intensity and low frequency. It is believed that the Ab-NWs vibrate transmitting a mechanical force to the targeted cells inducing cell death. © 2014 IEEE.

UR - http://hdl.handle.net/10754/564882

UR - http://ieeexplore.ieee.org/document/6783203/

UR - http://www.scopus.com/inward/record.url?scp=84900794791&partnerID=8YFLogxK

U2 - 10.1109/MECBME.2014.6783203

DO - 10.1109/MECBME.2014.6783203

M3 - Conference contribution

SN - 9781479947997

SP - 47

EP - 50

BT - 2nd Middle East Conference on Biomedical Engineering

PB - Institute of Electrical and Electronics Engineers (IEEE)

ER -

Targeted cancer cell death induced by biofunctionalized magnetic nanowires

Abstract

Bibliographical note

UN SDGs

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