Tailoring super-hydrophobic properties of electrochemical biosensor for early cancer detection

Natalia Malara; Francesco Gentile; Lorenzo Ferrara; Marco Villani; Salvatore Iannotta; Andrea Zappettini; Enzo M. Di Fabrizio; Valentina Trunzo; Vincenzo Mollace; Nicola Coppedé

doi:10.1557/adv.2016.543

Tailoring super-hydrophobic properties of electrochemical biosensor for early cancer detection

Natalia Malara, Francesco Gentile, Lorenzo Ferrara, Marco Villani, Salvatore Iannotta, Andrea Zappettini, Enzo M. Di Fabrizio, Valentina Trunzo, Vincenzo Mollace, Nicola Coppedé

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In this paper, we demonstrate an organic electrochemical transistor (OECT) based on the conductive polymer PEDOT:PSS for the analysis of the cell culture medium upon interaction with circulating cells isolated form peripheral blood sampling of health, sub-clinical and cancer patients. The device comprises arrays of super-hydrophobic micro-pillars in which a finite number of pillars incorporates nano-electrodes for site specific measurements of a solution. Due to its nano-scale architecture, the device realizes time and space resolved measurement of biological solution. Tumor metabolism could produce reactive species able to determine a different electronic behavior of correspondent microenviroment. On this basis, the device here presented the changes in the ESR signals was used to identify electronic changes occurring in the analysis of different type of microenvironment. Our results demonstrate that the device is able to register significative difference to differentiate healthy individuals form cancer patients, through an easy blood sampling. In conclusion, these preliminary data are suggestive of a novel test potentially useful to early identification of subjects at risk to development cancer disease.

Original language	English (US)
Pages (from-to)	3545-3552
Number of pages	8
Journal	MRS Advances
Volume	1
Issue number	52
DOIs	https://doi.org/10.1557/adv.2016.543
State	Published - Aug 5 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work has been partially funded from the Italian Minister of Health (Project n. GR-2010-2320665) and by the project Interregional Research Centre for Food Safety & health (IRC_FSH) (cod. PON a3-00359), granted to the Department of Health Science, University Magna Graecia. NC acknowledges Nicola Zambelli and Giacomo Benassi for technical support. NM acknowledges Prof. Bruno Silvestrini for scientific support. The authors would like to thank the patients and all health professionals involved at the University

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10.1557/adv.2016.543

https://repository.kaust.edu.sa/bitstream/10754/625234/1/tailoring_superhydrophobic_properties_of_electrochemical_biosensor_for_early_cancer_detection.pdf

Cite this

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title = "Tailoring super-hydrophobic properties of electrochemical biosensor for early cancer detection",

abstract = "In this paper, we demonstrate an organic electrochemical transistor (OECT) based on the conductive polymer PEDOT:PSS for the analysis of the cell culture medium upon interaction with circulating cells isolated form peripheral blood sampling of health, sub-clinical and cancer patients. The device comprises arrays of super-hydrophobic micro-pillars in which a finite number of pillars incorporates nano-electrodes for site specific measurements of a solution. Due to its nano-scale architecture, the device realizes time and space resolved measurement of biological solution. Tumor metabolism could produce reactive species able to determine a different electronic behavior of correspondent microenviroment. On this basis, the device here presented the changes in the ESR signals was used to identify electronic changes occurring in the analysis of different type of microenvironment. Our results demonstrate that the device is able to register significative difference to differentiate healthy individuals form cancer patients, through an easy blood sampling. In conclusion, these preliminary data are suggestive of a novel test potentially useful to early identification of subjects at risk to development cancer disease.",

author = "Natalia Malara and Francesco Gentile and Lorenzo Ferrara and Marco Villani and Salvatore Iannotta and Andrea Zappettini and {Di Fabrizio}, {Enzo M.} and Valentina Trunzo and Vincenzo Mollace and Nicola Copped{\'e}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work has been partially funded from the Italian Minister of Health (Project n. GR-2010-2320665) and by the project Interregional Research Centre for Food Safety & health (IRC_FSH) (cod. PON a3-00359), granted to the Department of Health Science, University Magna Graecia. NC acknowledges Nicola Zambelli and Giacomo Benassi for technical support. NM acknowledges Prof. Bruno Silvestrini for scientific support. The authors would like to thank the patients and all health professionals involved at the University",

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AU - Malara, Natalia

AU - Gentile, Francesco

AU - Ferrara, Lorenzo

AU - Villani, Marco

AU - Iannotta, Salvatore

AU - Zappettini, Andrea

AU - Di Fabrizio, Enzo M.

AU - Trunzo, Valentina

AU - Mollace, Vincenzo

AU - Coppedé, Nicola

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work has been partially funded from the Italian Minister of Health (Project n. GR-2010-2320665) and by the project Interregional Research Centre for Food Safety & health (IRC_FSH) (cod. PON a3-00359), granted to the Department of Health Science, University Magna Graecia. NC acknowledges Nicola Zambelli and Giacomo Benassi for technical support. NM acknowledges Prof. Bruno Silvestrini for scientific support. The authors would like to thank the patients and all health professionals involved at the University

PY - 2016/8/5

Y1 - 2016/8/5

N2 - In this paper, we demonstrate an organic electrochemical transistor (OECT) based on the conductive polymer PEDOT:PSS for the analysis of the cell culture medium upon interaction with circulating cells isolated form peripheral blood sampling of health, sub-clinical and cancer patients. The device comprises arrays of super-hydrophobic micro-pillars in which a finite number of pillars incorporates nano-electrodes for site specific measurements of a solution. Due to its nano-scale architecture, the device realizes time and space resolved measurement of biological solution. Tumor metabolism could produce reactive species able to determine a different electronic behavior of correspondent microenviroment. On this basis, the device here presented the changes in the ESR signals was used to identify electronic changes occurring in the analysis of different type of microenvironment. Our results demonstrate that the device is able to register significative difference to differentiate healthy individuals form cancer patients, through an easy blood sampling. In conclusion, these preliminary data are suggestive of a novel test potentially useful to early identification of subjects at risk to development cancer disease.

AB - In this paper, we demonstrate an organic electrochemical transistor (OECT) based on the conductive polymer PEDOT:PSS for the analysis of the cell culture medium upon interaction with circulating cells isolated form peripheral blood sampling of health, sub-clinical and cancer patients. The device comprises arrays of super-hydrophobic micro-pillars in which a finite number of pillars incorporates nano-electrodes for site specific measurements of a solution. Due to its nano-scale architecture, the device realizes time and space resolved measurement of biological solution. Tumor metabolism could produce reactive species able to determine a different electronic behavior of correspondent microenviroment. On this basis, the device here presented the changes in the ESR signals was used to identify electronic changes occurring in the analysis of different type of microenvironment. Our results demonstrate that the device is able to register significative difference to differentiate healthy individuals form cancer patients, through an easy blood sampling. In conclusion, these preliminary data are suggestive of a novel test potentially useful to early identification of subjects at risk to development cancer disease.

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ER -

Tailoring super-hydrophobic properties of electrochemical biosensor for early cancer detection

Abstract

Bibliographical note

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