TY - JOUR
T1 - Tailoring of bimetallic organic framework-polymeric film composites: Real-time fouling-free electrocatalytic application of hydrogen sulfide releasing from organic donors and live cells
AU - Kumaragurubaran, Namasivayam
AU - Arul, P.
AU - Huang, Sheng-Tung
AU - Nandhini, C.
AU - Mani, Veerappan
AU - Huang, Chih-Hung
N1 - KAUST Repository Item: Exported on 2023-02-27
Acknowledgements: The authors are grateful for the financial support from the Ministry of Science and Technology, Taiwan (MOST-107-2113-M-027-006 and MOST-108-2113-M-027-001). P. Arul would like to gratitude National Taipei University of Technology for the position of Research Assistant Professor.
PY - 2022/12/22
Y1 - 2022/12/22
N2 - Electrochemical real-time hydrogen sulfide (H2S) sensor in biological and chemical environments are great interest due to their impact of interferences and electrode-fouling effects. Hence, fouling-free detection of H2S is a key challenging to explore an unmasked electrocatalytic activity. In this context, a simple and robust strategy was developed based on bimetallic Ni-Co-MOF with poly(3,4-ethylenedioxythiophene) (PEDOTs) and poly(o-phenylenediamine) (PoPDA). The hybrid composite system exhibits tunable-structural morphology, cohesive electrical conductivity, strong interfacial chemical bonding and good anti-fouling property. The PEDOTs@Ni-Co-MOF/GCE yielded an enhanced catalytic performance with a concentration range of 1 nM to 250 µM, low detection limit of 0.186 nM, and high sensitivity (7.29 μA μM−1 cm−2). The water soluble GYY4137, and phosphordithioates-based donors were achieved dynamically quantify the real-time release of H2S against pH and co-incubation time (0–30 min). Additionally, bimetallic-MOF with the polymeric film platform achieved highly selective in other sulfur-containing complex medium and biomolecules due to its strong electrostatic net-charges and size exclusivity. A practical application was demonstrated in whole blood and biofluids with acceptable recoveries from 97.40 to 98.79 % (n = 3). The real-time endogenous release of H2S was evaluated in live cells (E. coli MG1655) by using a cysteine stimulator.
AB - Electrochemical real-time hydrogen sulfide (H2S) sensor in biological and chemical environments are great interest due to their impact of interferences and electrode-fouling effects. Hence, fouling-free detection of H2S is a key challenging to explore an unmasked electrocatalytic activity. In this context, a simple and robust strategy was developed based on bimetallic Ni-Co-MOF with poly(3,4-ethylenedioxythiophene) (PEDOTs) and poly(o-phenylenediamine) (PoPDA). The hybrid composite system exhibits tunable-structural morphology, cohesive electrical conductivity, strong interfacial chemical bonding and good anti-fouling property. The PEDOTs@Ni-Co-MOF/GCE yielded an enhanced catalytic performance with a concentration range of 1 nM to 250 µM, low detection limit of 0.186 nM, and high sensitivity (7.29 μA μM−1 cm−2). The water soluble GYY4137, and phosphordithioates-based donors were achieved dynamically quantify the real-time release of H2S against pH and co-incubation time (0–30 min). Additionally, bimetallic-MOF with the polymeric film platform achieved highly selective in other sulfur-containing complex medium and biomolecules due to its strong electrostatic net-charges and size exclusivity. A practical application was demonstrated in whole blood and biofluids with acceptable recoveries from 97.40 to 98.79 % (n = 3). The real-time endogenous release of H2S was evaluated in live cells (E. coli MG1655) by using a cysteine stimulator.
UR - http://hdl.handle.net/10754/688170
UR - https://linkinghub.elsevier.com/retrieve/pii/S0169433222036698
UR - http://www.scopus.com/inward/record.url?scp=85144578313&partnerID=8YFLogxK
U2 - 10.1016/j.apsusc.2022.156141
DO - 10.1016/j.apsusc.2022.156141
M3 - Article
SN - 1873-5584
VL - 613
SP - 156141
JO - APPLIED SURFACE SCIENCE
JF - APPLIED SURFACE SCIENCE
ER -