T cell receptor repertoire as a potential diagnostic marker for celiac disease.

Ying Yao, Asima Zia, Ralf Stefan Neumann, Milena Pavlovic, Gabriel Balaban, Knut E A Lundin, Geir Kjetil Sandve, Shuo-Wang Qiao

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


An individual's T cell repertoire is skewed towards some specificities as a result of past antigen exposure and subsequent clonal expansion. Identifying T cell receptor signatures associated with a disease is challenging due to the overall complexity of antigens and polymorphic HLA allotypes. In celiac disease, the antigen epitopes are well characterised and the specific HLA-DQ2-restricted T-cell repertoire associated with the disease has been explored in depth. By investigating T cell receptor repertoires of unsorted lamina propria T cells from 15 individuals, we provide the first proof-of-concept study showing that it could be possible to infer disease state by matching against a priori known disease-associated T cell receptor sequences.
Original languageEnglish (US)
Pages (from-to)108621
JournalClinical immunology (Orlando, Fla.)
StatePublished - Nov 16 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-11-19
Acknowledgements: The authors would like to thank Shiva Dahal-Koirala, Louise F Risnes and Ludvig M Sollid for access to the reference TCR database; and Victor Greiff for helpful comments and suggestions that improved the data processing.


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