T cell receptor repertoire as a potential diagnostic marker for celiac disease.

Ying Yao; Asima Zia; Ralf Stefan Neumann; Milena Pavlovic; Gabriel Balaban; Knut E A Lundin; Geir Kjetil Sandve; Shuo-Wang Qiao

doi:10.1016/j.clim.2020.108621

T cell receptor repertoire as a potential diagnostic marker for celiac disease.

Ying Yao, Asima Zia, Ralf Stefan Neumann, Milena Pavlovic, Gabriel Balaban, Knut E A Lundin, Geir Kjetil Sandve, Shuo-Wang Qiao

Biological, Environmental Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

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Abstract

An individual's T cell repertoire is skewed towards some specificities as a result of past antigen exposure and subsequent clonal expansion. Identifying T cell receptor signatures associated with a disease is challenging due to the overall complexity of antigens and polymorphic HLA allotypes. In celiac disease, the antigen epitopes are well characterised and the specific HLA-DQ2-restricted T-cell repertoire associated with the disease has been explored in depth. By investigating T cell receptor repertoires of unsorted lamina propria T cells from 15 individuals, we provide the first proof-of-concept study showing that it could be possible to infer disease state by matching against a priori known disease-associated T cell receptor sequences.

Original language	English (US)
Pages (from-to)	108621
Journal	Clinical immunology (Orlando, Fla.)
DOIs	https://doi.org/10.1016/j.clim.2020.108621
State	Published - Nov 16 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-11-19
Acknowledgements: The authors would like to thank Shiva Dahal-Koirala, Louise F Risnes and Ludvig M Sollid for access to the reference TCR database; and Victor Greiff for helpful comments and suggestions that improved the data processing.

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10.1016/j.clim.2020.108621

https://repository.kaust.edu.sa/bitstream/10754/666015/1/T%20cell%20receptors.pdf

Cite this

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title = "T cell receptor repertoire as a potential diagnostic marker for celiac disease.",

abstract = "An individual's T cell repertoire is skewed towards some specificities as a result of past antigen exposure and subsequent clonal expansion. Identifying T cell receptor signatures associated with a disease is challenging due to the overall complexity of antigens and polymorphic HLA allotypes. In celiac disease, the antigen epitopes are well characterised and the specific HLA-DQ2-restricted T-cell repertoire associated with the disease has been explored in depth. By investigating T cell receptor repertoires of unsorted lamina propria T cells from 15 individuals, we provide the first proof-of-concept study showing that it could be possible to infer disease state by matching against a priori known disease-associated T cell receptor sequences.",

author = "Ying Yao and Asima Zia and Neumann, {Ralf Stefan} and Milena Pavlovic and Gabriel Balaban and Lundin, {Knut E A} and Sandve, {Geir Kjetil} and Shuo-Wang Qiao",

note = "KAUST Repository Item: Exported on 2020-11-19 Acknowledgements: The authors would like to thank Shiva Dahal-Koirala, Louise F Risnes and Ludvig M Sollid for access to the reference TCR database; and Victor Greiff for helpful comments and suggestions that improved the data processing.",

year = "2020",

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doi = "10.1016/j.clim.2020.108621",

language = "English (US)",

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journal = "Clinical immunology (Orlando, Fla.)",

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T1 - T cell receptor repertoire as a potential diagnostic marker for celiac disease.

AU - Yao, Ying

AU - Zia, Asima

AU - Neumann, Ralf Stefan

AU - Pavlovic, Milena

AU - Balaban, Gabriel

AU - Lundin, Knut E A

AU - Sandve, Geir Kjetil

AU - Qiao, Shuo-Wang

N1 - KAUST Repository Item: Exported on 2020-11-19 Acknowledgements: The authors would like to thank Shiva Dahal-Koirala, Louise F Risnes and Ludvig M Sollid for access to the reference TCR database; and Victor Greiff for helpful comments and suggestions that improved the data processing.

PY - 2020/11/16

Y1 - 2020/11/16

N2 - An individual's T cell repertoire is skewed towards some specificities as a result of past antigen exposure and subsequent clonal expansion. Identifying T cell receptor signatures associated with a disease is challenging due to the overall complexity of antigens and polymorphic HLA allotypes. In celiac disease, the antigen epitopes are well characterised and the specific HLA-DQ2-restricted T-cell repertoire associated with the disease has been explored in depth. By investigating T cell receptor repertoires of unsorted lamina propria T cells from 15 individuals, we provide the first proof-of-concept study showing that it could be possible to infer disease state by matching against a priori known disease-associated T cell receptor sequences.

AB - An individual's T cell repertoire is skewed towards some specificities as a result of past antigen exposure and subsequent clonal expansion. Identifying T cell receptor signatures associated with a disease is challenging due to the overall complexity of antigens and polymorphic HLA allotypes. In celiac disease, the antigen epitopes are well characterised and the specific HLA-DQ2-restricted T-cell repertoire associated with the disease has been explored in depth. By investigating T cell receptor repertoires of unsorted lamina propria T cells from 15 individuals, we provide the first proof-of-concept study showing that it could be possible to infer disease state by matching against a priori known disease-associated T cell receptor sequences.

UR - http://hdl.handle.net/10754/666015

UR - https://linkinghub.elsevier.com/retrieve/pii/S1521661620307816

U2 - 10.1016/j.clim.2020.108621

DO - 10.1016/j.clim.2020.108621

M3 - Article

C2 - 33197618

SN - 1521-6616

SP - 108621

JO - Clinical immunology (Orlando, Fla.)

JF - Clinical immunology (Orlando, Fla.)

ER -

T cell receptor repertoire as a potential diagnostic marker for celiac disease.

Abstract

Bibliographical note

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