Synthetic Vehicles for Encapsulation and Delivery of CRISPR/Cas9 Gene Editing Machinery

Valentina Carboni, Carine Maaliki, Mram Z. Alyami, Shahad K. Alsaiari, Niveen M. Khashab

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated 9 (Cas-9) technology holds tremendous potential as a gene editing tool. Different strategies have been adopted for in vitro and in vivo delivery of CRISPR/Cas9, including both viral and non-viral. The possibility of tailoring properties of nanosized systems makes the molecular design of self-assembled non-viral delivery systems based on organic (lipids and polymers) and hybrid (zeolitic imidazolate frameworks, ZIF and gold nanoparticles) materials of a great interest in CRISPR/Cas9 delivery. This review highlights the progress and challenges of organic and hybrid CRISPR/Cas9 delivery vehicles.
Original languageEnglish (US)
Pages (from-to)1800085
JournalAdvanced Therapeutics
Issue number4
StatePublished - Feb 10 2019

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KAUST Repository Item: Exported on 2020-10-01


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