Synthetic strategies for efficient conjugation of organometallic complexes with pendant protein reactive markers

Dominik Jantke, Alexander N. Marziale, Thomas Reiner, Florian Kraus, Eberhardt Herdtweck, Andreas Raba, Jörg Eppinger

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Site-directed conjugation of metal centers to proteins is fundamental for biological and bioinorganic applications of transition metals. However, methods for the site-selective introduction of metal centers remain scarce. Herein, we present broadly applicable synthetic strategies for the conjugation of bioactive molecules with a range of organometallic complexes. Following three different synthetic strategies, we were able to synthesize a small library of metal conjugated protein markers featuring different types of protein reactive sites (epoxides, phenylphosphonates, fluorosulfonates and fluorophosphonate groups) as well as different late transition metals (iron, ruthenium, rhodium, palladium and platinum). The products were isolated in moderate to excellent yields and high purity. Furthermore, X-ray diffraction of the metalated protein markers corroborates structural integrity of the metal complex and the protein reactive site. © 2013 Elsevier B.V. All rights reserved.
Original languageEnglish (US)
Pages (from-to)82-91
Number of pages10
JournalJournal of Organometallic Chemistry
StatePublished - Nov 2013

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): FIC/2010/07
Acknowledgements: The authors thank Ramona Lex for help with crystallization. This work was supported by KAUST-GCR (FIC/2010/07) and the KAUST baseline fund (J.E.). We also thank the Elitenetzwerk Bayern for graduate fellowships for T.R. and A.N.M.

ASJC Scopus subject areas

  • Materials Chemistry
  • Biochemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Inorganic Chemistry


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