TY - JOUR
T1 - Synthetic Biology Open Language (SBOL) Version 2.3.
AU - Madsen, Curtis
AU - Goñi Moreno, Angel
AU - P, Umesh
AU - Palchick, Zachary
AU - Roehner, Nicholas
AU - Atallah, Christian
AU - Bartley, Bryan
AU - Choi, Kiri
AU - Cox, Robert Sidney
AU - Gorochowski, Thomas
AU - Grunberg, Raik
AU - Macklin, Chris
AU - McLaughlin, James
AU - Meng, Xianwei
AU - Nguyen, Tramy
AU - Pocock, Matthew
AU - Samineni, Meher
AU - Scott-Brown, James
AU - Tarter, Ysis
AU - Zhang, Michael
AU - Zhang, Zhen
AU - Zundel, Zach
AU - Beal, Jacob
AU - Bissell, Michael
AU - Clancy, Kevin
AU - Gennari, John H
AU - Misirli, Goksel
AU - Myers, Chris
AU - Oberortner, Ernst
AU - Sauro, Herbert
AU - Wipat, Anil
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2019/6/14
Y1 - 2019/6/14
N2 - Synthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. The field still faces substantial challenges, including long development times, high rates of failure, and poor reproducibility. One method to ameliorate these problems is to improve the exchange of information about designed systems between laboratories. The synthetic biology open language (SBOL) has been developed as a standard to support the specification and exchange of biological design information in synthetic biology, filling a need not satisfied by other pre-existing standards. This document details version 2.3.0 of SBOL, which builds upon version 2.2.0 published in last year's JIB Standards in Systems Biology special issue. In particular, SBOL 2.3.0 includes means of succinctly representing sequence modifications, such as insertion, deletion, and replacement, an extension to support organization and attachment of experimental data derived from designs, and an extension for describing numerical parameters of design elements. The new version also includes specifying types of synthetic biology activities, unambiguous locations for sequences with multiple encodings, refinement of a number of validation rules, improved figures and examples, and clarification on a number of issues related to the use of external ontology terms.
AB - Synthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. The field still faces substantial challenges, including long development times, high rates of failure, and poor reproducibility. One method to ameliorate these problems is to improve the exchange of information about designed systems between laboratories. The synthetic biology open language (SBOL) has been developed as a standard to support the specification and exchange of biological design information in synthetic biology, filling a need not satisfied by other pre-existing standards. This document details version 2.3.0 of SBOL, which builds upon version 2.2.0 published in last year's JIB Standards in Systems Biology special issue. In particular, SBOL 2.3.0 includes means of succinctly representing sequence modifications, such as insertion, deletion, and replacement, an extension to support organization and attachment of experimental data derived from designs, and an extension for describing numerical parameters of design elements. The new version also includes specifying types of synthetic biology activities, unambiguous locations for sequences with multiple encodings, refinement of a number of validation rules, improved figures and examples, and clarification on a number of issues related to the use of external ontology terms.
UR - http://hdl.handle.net/10754/656407
UR - http://www.degruyter.com/view/j/jib.ahead-of-print/jib-2019-0025/jib-2019-0025.xml
U2 - 10.1515/jib-2019-0025
DO - 10.1515/jib-2019-0025
M3 - Article
C2 - 31199770
SN - 1613-4516
VL - 16
JO - Journal of integrative bioinformatics
JF - Journal of integrative bioinformatics
IS - 2
ER -