Synthetic Biology Open Language (SBOL) Version 2.1.0

Jacob Beal, Robert Sidney Cox, Raik Grunberg, James McLaughlin, Tramy Nguyen, Bryan Bartley, Michael Bissell, Kiri Choi, Kevin Clancy, Chris Macklin, Curtis Madsen, Goksel Misirli, Ernst Oberortner, Matthew Pocock, Nicholas Roehner, Meher Samineni, Michael Zhang, Zhen Zhang, Zach Zundel, John H. GennariChris Myers, Herbert Sauro, Anil Wipat

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


SummarySynthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. The field still faces substantial challenges, including long development times, high rates of failure, and poor reproducibility. One method to ameliorate these problems would be to improve the exchange of information about designed systems between laboratories. The Synthetic Biology Open Language (SBOL) has been developed as a standard to support the specification and exchange of biological design information in synthetic biology, filling a need not satisfied by other pre-existing standards. This document details version 2.1 of SBOL that builds upon version 2.0 published in last year’s JIB special issue. In particular, SBOL 2.1 includes improved rules for what constitutes a valid SBOL document, new role fields to simplify the expression of sequence features and how components are used in context, and new best practices descriptions to improve the exchange of basic sequence topology information and the description of genetic design provenance, as well as miscellaneous other minor improvements.
Original languageEnglish (US)
Pages (from-to)30-132
Number of pages103
JournalJournal of integrative bioinformatics
Issue number3
StatePublished - Sep 1 2016

Bibliographical note

KAUST Repository Item: Exported on 2021-03-05

ASJC Scopus subject areas

  • General Medicine


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