Synthesis, spectral and antimicrobial activity of Zn(II) complexes with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde/2-hydroxyacetophenone/indoline-2,3-dione

Ajay K. Singh; O. P. Pandey; S. K. Sengupta

doi:10.1016/j.saa.2013.04.045

Synthesis, spectral and antimicrobial activity of Zn(II) complexes with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde/2-hydroxyacetophenone/indoline-2,3-dione

Ajay K. Singh, O. P. Pandey, S. K. Sengupta^*

^*Corresponding author for this work

Earth Science and Engineering

Research output: Contribution to journal › Article › peer-review

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Abstract

(Chemical Equation Presented) Zn(II) complexes have been synthesized by reacting zinc acetate with Schiff bases derived from 2-hydrazino- 5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/benzaldehyde/indoline-2, 3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non electrolytes. Elemental analyses suggest that the complexes have 1:2 metal to ligands stoichiometry of the types [ZnL ₂(H₂O)₂](L = monoanionic Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/indoline-2,3-dione) [ZnL′₂(OOCCH ₃)₂(H₂O)₂] (L′ = neutral Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde), and they were characterized by IR, ¹H NMR, and ¹³C NMR. Particle sizes of synthesized compounds were measured with dynamic light scattering (DLS) analyser which indicates that particle diameter are of the range ca. 100-200 nm. All these Schiff bases and their complexes have also been screened for their antibacterial (Bacillus subtilis (B. subtilis), Escherichia coli (E. coli) and antifungal activities (Colletotrichum falcatum (C. falcatum), Aspergillus niger (A. niger), Fusarium oxysporium (F. oxysporium) Curvularia pallescence (C. pallescence). The antimicrobial activities have shown that upon complexation the activity increases.

Original language	English (US)
Pages (from-to)	393-399
Number of pages	7
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	113
DOIs	https://doi.org/10.1016/j.saa.2013.04.045
State	Published - Sep 2013

Keywords

Antibacterial
Antifungal
DLS analysis
Schiff bases
Zn(II) complexes

ASJC Scopus subject areas

Analytical Chemistry
Atomic and Molecular Physics, and Optics
Instrumentation
Spectroscopy

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Singh, A. K., Pandey, O. P., & Sengupta, S. K. (2013). Synthesis, spectral and antimicrobial activity of Zn(II) complexes with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde/2-hydroxyacetophenone/indoline-2,3-dione. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 113, 393-399. https://doi.org/10.1016/j.saa.2013.04.045

@article{be52505c39fd4e539bd7583c75e86883,

title = "Synthesis, spectral and antimicrobial activity of Zn(II) complexes with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde/2-hydroxyacetophenone/indoline-2,3-dione",

abstract = "(Chemical Equation Presented) Zn(II) complexes have been synthesized by reacting zinc acetate with Schiff bases derived from 2-hydrazino- 5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/benzaldehyde/indoline-2, 3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non electrolytes. Elemental analyses suggest that the complexes have 1:2 metal to ligands stoichiometry of the types [ZnL 2(H2O)2](L = monoanionic Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/indoline-2,3-dione) [ZnL′2(OOCCH 3)2(H2O)2] (L′ = neutral Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde), and they were characterized by IR, 1H NMR, and 13C NMR. Particle sizes of synthesized compounds were measured with dynamic light scattering (DLS) analyser which indicates that particle diameter are of the range ca. 100-200 nm. All these Schiff bases and their complexes have also been screened for their antibacterial (Bacillus subtilis (B. subtilis), Escherichia coli (E. coli) and antifungal activities (Colletotrichum falcatum (C. falcatum), Aspergillus niger (A. niger), Fusarium oxysporium (F. oxysporium) Curvularia pallescence (C. pallescence). The antimicrobial activities have shown that upon complexation the activity increases.",

keywords = "Antibacterial, Antifungal, DLS analysis, Schiff bases, Zn(II) complexes",

author = "Singh, {Ajay K.} and Pandey, {O. P.} and Sengupta, {S. K.}",

year = "2013",

month = sep,

doi = "10.1016/j.saa.2013.04.045",

language = "English (US)",

volume = "113",

pages = "393--399",

journal = "Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy",

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publisher = "Elsevier",

}

Singh, AK, Pandey, OP & Sengupta, SK 2013, 'Synthesis, spectral and antimicrobial activity of Zn(II) complexes with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde/2-hydroxyacetophenone/indoline-2,3-dione', Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, vol. 113, pp. 393-399. https://doi.org/10.1016/j.saa.2013.04.045

Synthesis, spectral and antimicrobial activity of Zn(II) complexes with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde/2-hydroxyacetophenone/indoline-2,3-dione. / Singh, Ajay K.; Pandey, O. P.; Sengupta, S. K.
In: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Vol. 113, 09.2013, p. 393-399.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis, spectral and antimicrobial activity of Zn(II) complexes with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde/2-hydroxyacetophenone/indoline-2,3-dione

AU - Singh, Ajay K.

AU - Pandey, O. P.

AU - Sengupta, S. K.

PY - 2013/9

Y1 - 2013/9

N2 - (Chemical Equation Presented) Zn(II) complexes have been synthesized by reacting zinc acetate with Schiff bases derived from 2-hydrazino- 5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/benzaldehyde/indoline-2, 3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non electrolytes. Elemental analyses suggest that the complexes have 1:2 metal to ligands stoichiometry of the types [ZnL 2(H2O)2](L = monoanionic Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/indoline-2,3-dione) [ZnL′2(OOCCH 3)2(H2O)2] (L′ = neutral Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde), and they were characterized by IR, 1H NMR, and 13C NMR. Particle sizes of synthesized compounds were measured with dynamic light scattering (DLS) analyser which indicates that particle diameter are of the range ca. 100-200 nm. All these Schiff bases and their complexes have also been screened for their antibacterial (Bacillus subtilis (B. subtilis), Escherichia coli (E. coli) and antifungal activities (Colletotrichum falcatum (C. falcatum), Aspergillus niger (A. niger), Fusarium oxysporium (F. oxysporium) Curvularia pallescence (C. pallescence). The antimicrobial activities have shown that upon complexation the activity increases.

AB - (Chemical Equation Presented) Zn(II) complexes have been synthesized by reacting zinc acetate with Schiff bases derived from 2-hydrazino- 5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/benzaldehyde/indoline-2, 3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non electrolytes. Elemental analyses suggest that the complexes have 1:2 metal to ligands stoichiometry of the types [ZnL 2(H2O)2](L = monoanionic Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/indoline-2,3-dione) [ZnL′2(OOCCH 3)2(H2O)2] (L′ = neutral Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde), and they were characterized by IR, 1H NMR, and 13C NMR. Particle sizes of synthesized compounds were measured with dynamic light scattering (DLS) analyser which indicates that particle diameter are of the range ca. 100-200 nm. All these Schiff bases and their complexes have also been screened for their antibacterial (Bacillus subtilis (B. subtilis), Escherichia coli (E. coli) and antifungal activities (Colletotrichum falcatum (C. falcatum), Aspergillus niger (A. niger), Fusarium oxysporium (F. oxysporium) Curvularia pallescence (C. pallescence). The antimicrobial activities have shown that upon complexation the activity increases.

KW - Antibacterial

KW - Antifungal

KW - DLS analysis

KW - Schiff bases

KW - Zn(II) complexes

UR - http://www.scopus.com/inward/record.url?scp=84878496852&partnerID=8YFLogxK

U2 - 10.1016/j.saa.2013.04.045

DO - 10.1016/j.saa.2013.04.045

M3 - Article

C2 - 23747379

AN - SCOPUS:84878496852

SN - 1386-1425

VL - 113

SP - 393

EP - 399

JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

ER -

Synthesis, spectral and antimicrobial activity of Zn(II) complexes with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde/2-hydroxyacetophenone/indoline-2,3-dione

Abstract

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ASJC Scopus subject areas

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