Synthesis of well-defined poly(N-isopropylacrylamide)-b-poly(L-glutamic acid) by a versatile approach and micellization

Lin Deng; Keyu Shi; Yuying Zhang; Haimei Wang; Jianguo Zeng; Xianzhi Guo; Zongjie Du; Baolong Zhang

doi:10.1016/j.jcis.2008.04.007

Synthesis of well-defined poly(N-isopropylacrylamide)-b-poly(L-glutamic acid) by a versatile approach and micellization

Lin Deng, Keyu Shi^*, Yuying Zhang, Haimei Wang, Jianguo Zeng, Xianzhi Guo, Zongjie Du, Baolong Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A novel Fmoc-protected chain transfer agent (CTA) was synthesized and applied in the reversible addition-fragmentation chain transfer (RAFT) polymerization of N-isopropylacrylamide (NIPAAm), resulting in well-defined Fmoc-protected PNIPAAm and the amino-end capped PNIPAAm by the subsequent hydrolysis. Poly(N-isopropylacrylamide)-b-poly(l-glutamic acid) (PNIPAAm-b-PLGA) with controlled molecular weight and narrow molecular weight distribution was synthesized successfully via ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs) by using PNIPAAm-NH₂ as the macroinitiator. Both pH- and thermo-responsive micellization behaviors of the block copolymer PNIPAAm₅₅-b-PLGA₃₅ in dilute aqueous solution were investigated by means of the pyrene fluorescence, circular dichroism, ¹H NMR, transmission electron microscopy and dynamic and static light scattering. Spherical PLGA-core and rod-like PNIPAAm-core micelles are formed in response to pH and temperature. The reversible transition between the PLGA-core and PNIPAAm-core micelles was observed. This work provides a versatile approach for synthesizing well-defined stimuli-responsive polypeptide-based double hydrophilic diblock copolymers (DHBCs), and is of great potential for generating useful stimuli-responsive materials in biomedical applications.

Original language	English (US)
Pages (from-to)	169-175
Number of pages	7
Journal	Journal of colloid and interface science
Volume	323
Issue number	1
DOIs	https://doi.org/10.1016/j.jcis.2008.04.007
State	Published - Jul 1 2008
Externally published	Yes

Keywords

Micellization
Polypeptide-based block copolymer
Thermo-responsive
pH-responsive

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Surfaces, Coatings and Films
Biomaterials
Colloid and Surface Chemistry

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10.1016/j.jcis.2008.04.007

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title = "Synthesis of well-defined poly(N-isopropylacrylamide)-b-poly(L-glutamic acid) by a versatile approach and micellization",

abstract = "A novel Fmoc-protected chain transfer agent (CTA) was synthesized and applied in the reversible addition-fragmentation chain transfer (RAFT) polymerization of N-isopropylacrylamide (NIPAAm), resulting in well-defined Fmoc-protected PNIPAAm and the amino-end capped PNIPAAm by the subsequent hydrolysis. Poly(N-isopropylacrylamide)-b-poly(l-glutamic acid) (PNIPAAm-b-PLGA) with controlled molecular weight and narrow molecular weight distribution was synthesized successfully via ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs) by using PNIPAAm-NH2 as the macroinitiator. Both pH- and thermo-responsive micellization behaviors of the block copolymer PNIPAAm55-b-PLGA35 in dilute aqueous solution were investigated by means of the pyrene fluorescence, circular dichroism, 1H NMR, transmission electron microscopy and dynamic and static light scattering. Spherical PLGA-core and rod-like PNIPAAm-core micelles are formed in response to pH and temperature. The reversible transition between the PLGA-core and PNIPAAm-core micelles was observed. This work provides a versatile approach for synthesizing well-defined stimuli-responsive polypeptide-based double hydrophilic diblock copolymers (DHBCs), and is of great potential for generating useful stimuli-responsive materials in biomedical applications.",

keywords = "Micellization, Polypeptide-based block copolymer, Thermo-responsive, pH-responsive",

author = "Lin Deng and Keyu Shi and Yuying Zhang and Haimei Wang and Jianguo Zeng and Xianzhi Guo and Zongjie Du and Baolong Zhang",

year = "2008",

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doi = "10.1016/j.jcis.2008.04.007",

language = "English (US)",

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pages = "169--175",

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T1 - Synthesis of well-defined poly(N-isopropylacrylamide)-b-poly(L-glutamic acid) by a versatile approach and micellization

AU - Deng, Lin

AU - Shi, Keyu

AU - Zhang, Yuying

AU - Wang, Haimei

AU - Zeng, Jianguo

AU - Guo, Xianzhi

AU - Du, Zongjie

AU - Zhang, Baolong

PY - 2008/7/1

Y1 - 2008/7/1

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AB - A novel Fmoc-protected chain transfer agent (CTA) was synthesized and applied in the reversible addition-fragmentation chain transfer (RAFT) polymerization of N-isopropylacrylamide (NIPAAm), resulting in well-defined Fmoc-protected PNIPAAm and the amino-end capped PNIPAAm by the subsequent hydrolysis. Poly(N-isopropylacrylamide)-b-poly(l-glutamic acid) (PNIPAAm-b-PLGA) with controlled molecular weight and narrow molecular weight distribution was synthesized successfully via ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs) by using PNIPAAm-NH2 as the macroinitiator. Both pH- and thermo-responsive micellization behaviors of the block copolymer PNIPAAm55-b-PLGA35 in dilute aqueous solution were investigated by means of the pyrene fluorescence, circular dichroism, 1H NMR, transmission electron microscopy and dynamic and static light scattering. Spherical PLGA-core and rod-like PNIPAAm-core micelles are formed in response to pH and temperature. The reversible transition between the PLGA-core and PNIPAAm-core micelles was observed. This work provides a versatile approach for synthesizing well-defined stimuli-responsive polypeptide-based double hydrophilic diblock copolymers (DHBCs), and is of great potential for generating useful stimuli-responsive materials in biomedical applications.

KW - Micellization

KW - Polypeptide-based block copolymer

KW - Thermo-responsive

KW - pH-responsive

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IS - 1

ER -

Synthesis of well-defined poly(N-isopropylacrylamide)-b-poly(L-glutamic acid) by a versatile approach and micellization

Abstract

Keywords

ASJC Scopus subject areas

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