Synthesis of well-defined functional macromolecular chimeras based on poly(ethylene oxide) or poly(N-vinyl pyrrolidone)

A. Karatzas, P. Bilalis, H. Iatrou, M. Pitsikalis, N. Hadjichristidis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


By using either NH2-functionalized linear/4-arm star poly(ethylene oxide) or NH2-TEMPO initiator, the following novel polymer/polypeptide hybrids (macromolecular chimeras) of poly(ethylene oxide), PEO and poly(N-vinyl pyrrolidone), PNVP, were synthesized: PEO-b-(PBLG or PBLL), PEO-b-PBLL-b-PBLG, 4-arm star copolymer (PEO-b-PBLG)4, PNVP-b-PBLG-b-PBLL, where PBLG is poly(γ-benzyl-l-glutamate) and PBLL, poly(tert-butyloxycarbonyl-l-lysine). The amino-groups are used for the ring opening polymerization (ROP) of α-amino acid carboxyanhydrides (NCAs), while TEMPO was employed for the polymerization of NVP. Molecular characterization revealed the high molecular weight and compositional homogeneity of the macromolecular chimeras prepared. The success of the synthesis was based on the recently developed living ROP of NCAs and controlled/living TEMPO polymerization, using high vacuum techniques.

Original languageEnglish (US)
Pages (from-to)435-440
Number of pages6
JournalReactive and Functional Polymers
Issue number7
StatePublished - Jul 2009

Bibliographical note

Funding Information:
The financial support of the Ministry of Education through the Operational Program and Initial Educational Vocational Training on “Polymer Science and its Applications” and the Research Committee of the University of Athens is greatly appreciated.


  • Nitroxide mediated radical polymerization
  • Poly(N-vinyl pyrrolidone)
  • Poly(ethylene oxide)
  • Polypeptides
  • Ring opening polymerization

ASJC Scopus subject areas

  • General Chemistry
  • Environmental Chemistry
  • Biochemistry
  • General Chemical Engineering
  • Polymers and Plastics
  • Materials Chemistry


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