A new method for the synthesis of trifluoromethylated acetylenes is developed which involves the copper-catalyzed trifluoromethylation of alkynyltrifluoroborates with an electrophilic trifluoromethylating reagent. This method offers significant advantages such as efficiency and mild and base-free reaction conditions. A plausible mechanism is proposed. © 2012 Elsevier Ltd. All rights reserved.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Dec 2012|
Bibliographical noteKAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We acknowledge financial support from the National Natural Science Foundation of China (21072030) and the Fuzhou University (022318) to Z.W. and the King Abdullah University of Science and Technology to K.-W.H.
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery