Synthesis of trifluoromethylated acetylenes via copper-catalyzed trifluoromethylation of alkynyltrifluoroborates

Huidong Zheng; Yuanyuan Huang; Zhiwei Wang; Huaifeng Li; Kuo-Wei Huang; Yaofeng Yuan; Zhiqiang Weng

doi:10.1016/j.tetlet.2012.09.083

Synthesis of trifluoromethylated acetylenes via copper-catalyzed trifluoromethylation of alkynyltrifluoroborates

Huidong Zheng, Yuanyuan Huang, Zhiwei Wang, Huaifeng Li, Kuo-Wei Huang, Yaofeng Yuan, Zhiqiang Weng

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A new method for the synthesis of trifluoromethylated acetylenes is developed which involves the copper-catalyzed trifluoromethylation of alkynyltrifluoroborates with an electrophilic trifluoromethylating reagent. This method offers significant advantages such as efficiency and mild and base-free reaction conditions. A plausible mechanism is proposed. © 2012 Elsevier Ltd. All rights reserved.

Original language	English (US)
Pages (from-to)	6646-6649
Number of pages	4
Journal	Tetrahedron Letters
Volume	53
Issue number	49
DOIs	https://doi.org/10.1016/j.tetlet.2012.09.083
State	Published - Dec 2012

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We acknowledge financial support from the National Natural Science Foundation of China (21072030) and the Fuzhou University (022318) to Z.W. and the King Abdullah University of Science and Technology to K.-W.H.

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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10.1016/j.tetlet.2012.09.083

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abstract = "A new method for the synthesis of trifluoromethylated acetylenes is developed which involves the copper-catalyzed trifluoromethylation of alkynyltrifluoroborates with an electrophilic trifluoromethylating reagent. This method offers significant advantages such as efficiency and mild and base-free reaction conditions. A plausible mechanism is proposed. {\textcopyright} 2012 Elsevier Ltd. All rights reserved.",

author = "Huidong Zheng and Yuanyuan Huang and Zhiwei Wang and Huaifeng Li and Kuo-Wei Huang and Yaofeng Yuan and Zhiqiang Weng",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: We acknowledge financial support from the National Natural Science Foundation of China (21072030) and the Fuzhou University (022318) to Z.W. and the King Abdullah University of Science and Technology to K.-W.H.",

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AU - Zheng, Huidong

AU - Huang, Yuanyuan

AU - Wang, Zhiwei

AU - Li, Huaifeng

AU - Huang, Kuo-Wei

AU - Yuan, Yaofeng

AU - Weng, Zhiqiang

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: We acknowledge financial support from the National Natural Science Foundation of China (21072030) and the Fuzhou University (022318) to Z.W. and the King Abdullah University of Science and Technology to K.-W.H.

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AB - A new method for the synthesis of trifluoromethylated acetylenes is developed which involves the copper-catalyzed trifluoromethylation of alkynyltrifluoroborates with an electrophilic trifluoromethylating reagent. This method offers significant advantages such as efficiency and mild and base-free reaction conditions. A plausible mechanism is proposed. © 2012 Elsevier Ltd. All rights reserved.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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Synthesis of trifluoromethylated acetylenes via copper-catalyzed trifluoromethylation of alkynyltrifluoroborates

Abstract

Bibliographical note

ASJC Scopus subject areas

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