Synthesis of trifluoromethylated acetylenes via copper-catalyzed trifluoromethylation of alkynyltrifluoroborates

Huidong Zheng, Yuanyuan Huang, Zhiwei Wang, Huaifeng Li, Kuo-Wei Huang, Yaofeng Yuan, Zhiqiang Weng

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


A new method for the synthesis of trifluoromethylated acetylenes is developed which involves the copper-catalyzed trifluoromethylation of alkynyltrifluoroborates with an electrophilic trifluoromethylating reagent. This method offers significant advantages such as efficiency and mild and base-free reaction conditions. A plausible mechanism is proposed. © 2012 Elsevier Ltd. All rights reserved.
Original languageEnglish (US)
Pages (from-to)6646-6649
Number of pages4
JournalTetrahedron Letters
Issue number49
StatePublished - Dec 2012

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We acknowledge financial support from the National Natural Science Foundation of China (21072030) and the Fuzhou University (022318) to Z.W. and the King Abdullah University of Science and Technology to K.-W.H.

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery


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