Synthesis of reduced-size gold nanostars and internalization in SH-SY5Y cells

Giacomo Dacarro; Piersandro Pallavicini; Serena Maria Bertani; Giuseppe Chirico; Laura D'Alfonso; Andrea Falqui; Nicoletta Marchesi; Alessia Pascale; Laura Sironi; Angelo Taglietti; Efisio Zuddas

doi:10.1016/j.jcis.2017.06.102

Synthesis of reduced-size gold nanostars and internalization in SH-SY5Y cells

Giacomo Dacarro, Piersandro Pallavicini, Serena Maria Bertani, Giuseppe Chirico, Laura D'Alfonso, Andrea Falqui, Nicoletta Marchesi, Alessia Pascale, Laura Sironi, Angelo Taglietti, Efisio Zuddas

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16 Scopus citations

Abstract

The synthesis of large pentatwinned five-branched gold nanostars (GNS) has been modified so to obtain overall dimensions shrunk to 60% and a lower branches aspect ratio, leading to a dramatic blue shift of their two near-infrared (NIR) localized surface plasmon resonances (LSPR) absorptions but still maintaining one LSPR in the biotransparent NIR range. The interactions of polyethylene glycol (PEG) coated large and shrunk GNS with SH-SY5Y cells revealed that the large ones (DCI - diameter of the circumference in which GNS can be inscribed = 76 nm) are internalized more efficiently than the shrunk ones (DCI = 46 nm), correlating with a decreased cells surving fraction.

Original language	English (US)
Pages (from-to)	1055-1064
Number of pages	10
Journal	Journal of Colloid and Interface Science
Volume	505
DOIs	https://doi.org/10.1016/j.jcis.2017.06.102
State	Published - Jul 1 2017

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by the Italian Ministry of Instruction, University and Research (MIUR) and by PRIN 2010–11 [20109PLMH2]. The University of Pavia and CIRCMSB (Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici) are also gratefully acknowledged for support. LD would like to thank Sara Oprandi for her help in collecting the photothermal response data.

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10.1016/j.jcis.2017.06.102

https://repository.kaust.edu.sa/bitstream/10754/625151/1/1-s2.0-S0021979717307671-main.pdf

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@article{4ee45e97cc5d42c5a34cc42a40bd49d1,

title = "Synthesis of reduced-size gold nanostars and internalization in SH-SY5Y cells",

abstract = "The synthesis of large pentatwinned five-branched gold nanostars (GNS) has been modified so to obtain overall dimensions shrunk to 60% and a lower branches aspect ratio, leading to a dramatic blue shift of their two near-infrared (NIR) localized surface plasmon resonances (LSPR) absorptions but still maintaining one LSPR in the biotransparent NIR range. The interactions of polyethylene glycol (PEG) coated large and shrunk GNS with SH-SY5Y cells revealed that the large ones (DCI - diameter of the circumference in which GNS can be inscribed = 76 nm) are internalized more efficiently than the shrunk ones (DCI = 46 nm), correlating with a decreased cells surving fraction.",

author = "Giacomo Dacarro and Piersandro Pallavicini and Bertani, {Serena Maria} and Giuseppe Chirico and Laura D'Alfonso and Andrea Falqui and Nicoletta Marchesi and Alessia Pascale and Laura Sironi and Angelo Taglietti and Efisio Zuddas",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by the Italian Ministry of Instruction, University and Research (MIUR) and by PRIN 2010–11 [20109PLMH2]. The University of Pavia and CIRCMSB (Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici) are also gratefully acknowledged for support. LD would like to thank Sara Oprandi for her help in collecting the photothermal response data.",

year = "2017",

month = jul,

day = "1",

doi = "10.1016/j.jcis.2017.06.102",

language = "English (US)",

volume = "505",

pages = "1055--1064",

journal = "Journal of Colloid and Interface Science",

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T1 - Synthesis of reduced-size gold nanostars and internalization in SH-SY5Y cells

AU - Dacarro, Giacomo

AU - Pallavicini, Piersandro

AU - Bertani, Serena Maria

AU - Chirico, Giuseppe

AU - D'Alfonso, Laura

AU - Falqui, Andrea

AU - Marchesi, Nicoletta

AU - Pascale, Alessia

AU - Sironi, Laura

AU - Taglietti, Angelo

AU - Zuddas, Efisio

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by the Italian Ministry of Instruction, University and Research (MIUR) and by PRIN 2010–11 [20109PLMH2]. The University of Pavia and CIRCMSB (Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici) are also gratefully acknowledged for support. LD would like to thank Sara Oprandi for her help in collecting the photothermal response data.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - The synthesis of large pentatwinned five-branched gold nanostars (GNS) has been modified so to obtain overall dimensions shrunk to 60% and a lower branches aspect ratio, leading to a dramatic blue shift of their two near-infrared (NIR) localized surface plasmon resonances (LSPR) absorptions but still maintaining one LSPR in the biotransparent NIR range. The interactions of polyethylene glycol (PEG) coated large and shrunk GNS with SH-SY5Y cells revealed that the large ones (DCI - diameter of the circumference in which GNS can be inscribed = 76 nm) are internalized more efficiently than the shrunk ones (DCI = 46 nm), correlating with a decreased cells surving fraction.

AB - The synthesis of large pentatwinned five-branched gold nanostars (GNS) has been modified so to obtain overall dimensions shrunk to 60% and a lower branches aspect ratio, leading to a dramatic blue shift of their two near-infrared (NIR) localized surface plasmon resonances (LSPR) absorptions but still maintaining one LSPR in the biotransparent NIR range. The interactions of polyethylene glycol (PEG) coated large and shrunk GNS with SH-SY5Y cells revealed that the large ones (DCI - diameter of the circumference in which GNS can be inscribed = 76 nm) are internalized more efficiently than the shrunk ones (DCI = 46 nm), correlating with a decreased cells surving fraction.

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DO - 10.1016/j.jcis.2017.06.102

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SN - 0021-9797

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SP - 1055

EP - 1064

JO - Journal of Colloid and Interface Science

JF - Journal of Colloid and Interface Science

ER -

Synthesis of reduced-size gold nanostars and internalization in SH-SY5Y cells

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